Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
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DOI：
10.1002/ajmg.b.30187
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发表时间：
2005-07-05
影响因子：
2.8
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Chen, CK;Lin, SK;Murray, RM
目前尚不清楚为什么一些甲基苯丙胺（MAMP）滥用者会出现精神病症状，而另一些人则长期定期使用MAMP而毫发无损。我们测试的假设，这些用户谁开发MAMP诱导的精神病（MIP）有更大的家庭负荷的精神障碍比用户没有精神病。从台北市精神病院和看守所招募了445名MAMP使用者，并进行了遗传研究诊断访谈（DIGS-C）和遗传研究家庭访谈（FIGS-C）的评估。比较了那些终生诊断为MAMP精神病的MAMP使用者和那些没有MAMP精神病的MAMP使用者的一级亲属中精神疾病的发病风险（MR）。MAMP使用者亲属中有精神病史者的精神分裂症MR显著高于先证者亲属（OR=5.4，95% CI：2.0-14.7，P < 0.001）。此外，长期MAMP精神病（MIP-P）患者亲属的精神分裂症MR高于短期MAMP精神病（MIP-B）患者亲属（OR=2.8，95%CI：1.0-8.0，P = 0.042）。他或她的精神分裂症家族负荷越大，MAMP使用者越有可能发展为精神病，并且精神病可能持续的时间越长。(c)2005 Wiley-Liss，Inc.
It is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP-induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty-five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS-C) and the Family Interview for genetic study (FIGS-C). Morbid risk (MR) for psychiatric disorders in first-degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR=5.4, 95% CI: 2.0-14.7, P < 0.001) than the relatives of those probands who never became psychotic. Furthermore, the MR for schizophrenia in the relatives of the subjects with a prolonged MAMP psychosis (MIP-P) was higher than in the relatives of those users with a brief MAMP psychosis (MIP-B) (OR=2.8, 95% CI: 1.0-8.0, P = 0.042). The greater his or her familial loading for schizophrenia, the more likely a MAMP user is to develop psychosis, and the longer that psychosis is likely to last. (c) 2005 Wiley-Liss, Inc.