On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat.
On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat.
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DOI：
10.1113/jphysiol.1981.sp013664
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发表时间：
1981-04
期刊：
影响因子：
--
通讯作者：
K. Horch;S. Lisney
中科院分区：
文献类型：
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作者：
K. Horch;S. Lisney
1.使用电生理学和解剖学技术来研究猫的正常和再生腓肠和股后皮神经纤维。 2. 横断这些神经一年半后，发现再生的神经元在神经远端残端支持多个芽。分支发生在神经瘤的水平或之外，并且一些分支纤维支配皮肤上的分裂感受野。 3. 对横断神经近端残端轴突数量的计数表明，整个原始髓鞘纤维群持续了至少 18 个月。大约 75% 的这些纤维成功穿过未修复的横断部位并再生到神经的远端残端，以重新形成皮肤中的功能连接。 4. 神经挤压后，所有有髓轴突均再生。没有一个显示出异常分支的迹象。 5.粉碎后，神经远端残端再生轴突的传导速度在6个月时达到接近正常值。神经横断后，即使在损伤后 18 个月，远端传导速度仍降至正常值的 50%。 6. 讨论了这些发现对人类神经损伤后功能恢复的影响。
1. Electrophysiological and anatomical techniques were used to investigate normal and regenerating sural and posterior femoral cutaneous nerve fibres in the cat. 2. One and a half years after transection of these nerves it was found that the regenerating neurones supported multiple sprouts in the distal stump of the nerve. The branching occurred at or beyond the level of the neuroma and some of the branched fibres innervated split receptive fields on the skin. 3. Counts of the number of axons in the proximal stumps of transected nerves showed that the whole original population of myelinated fibres persisted for at least 18 months. About 75% of these fibres successfully crossed the unrepaired transection site and regenerated into the distal stump of the nerve to re‐form functional connexions in the skin. 4. After nerve crush all the myelinated axons regenerated. None showed signs of abnormal branching. 5. After crush the conduction velocities of the regenerated axons in the distal stump of the nerve reached nearly normal values by 6 months. After nerve transection the distal conduction velocities were reduced to 50% of normal even 18 months after the injury. 6. The implications of these findings for the recovery of function after nerve injury in man are discussed.