Bile Sensing: The Activation of Vibrio parahaemolyticus Virulence.
Bile Sensing: The Activation of Vibrio parahaemolyticus Virulence.
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DOI：
10.3389/fmicb.2017.00728
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发表时间：
2017
影响因子：
5.2
通讯作者：
Lee LH
中科院分区：
文献类型：
--
作者：
Letchumanan V;Chan KG;Khan TM;Bukhari SI;Ab Mutalib NS;Goh BH;Lee LH
细菌必须对各种不适宜生存的条件产生抗性，以便在人类胃肠道中存活。胆汁由肝脏分泌，在食物消化中起着重要作用，也具有抗菌特性，能够破坏细胞内稳态。奇怪的是，虽然胆汁是肠道防御系统之一，但许多研究报告称，副溶血性弧菌等细菌可以感知胆汁，并将其作为环境线索，在感染过程中上调毒力基因。本文旨在讨论副溶血性弧菌如何检测胆汁及其在调节III型分泌系统2导致人类感染中的作用。这种胆汁-细菌相互作用途径使我们更清楚地了解参与介导对胆汁盐反应的细菌受体的生化和结构分析，胆汁盐似乎是感染开始期间的重要环境线索。
Bacteria must develop resistance to various inhospitable conditions in order to survive in the human gastrointestinal tract. Bile, which is secreted by the liver, and plays an important role in food digestion also has antimicrobial properties and is able to disrupt cellular homeostasis. Paradoxically, although bile is one of the guts defenses, many studies have reported that bacteria such as Vibrio parahaemolyticus can sense bile and use its presence as an environmental cue to upregulate virulence genes during infection. This article aims to discuss how bile is detected by V. parahaemolyticus and its role in regulating type III secretion system 2 leading to human infection. This bile–bacteria interaction pathway gives us a clearer understanding of the biochemical and structural analysis of the bacterial receptors involved in mediating a response to bile salts which appear to be a significant environmental cue during initiation of an infection.