ELECTRON-MICROSCOPIC STUDY ON CELL-DIFFERENTIATION IN ANAGEN HAIR-FOLLICLES IN MICE
ELECTRON-MICROSCOPIC STUDY ON CELL-DIFFERENTIATION IN ANAGEN HAIR-FOLLICLES IN MICE
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DOI：
10.1111/1523-1747.ep12462569
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发表时间：
1988-01-01
影响因子：
6.5
通讯作者：
ITO, M
中科院分区：
文献类型：
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作者：
ITO, M
对几个品系7日龄小鼠的背侧毛囊和鼻窦毛囊进行了超微结构观察，以研究它们的细胞分化。这些发现与人类生长期毛囊中的研究结果进行了比较。在小鼠，Henle‘S’和‘Huxley’S层的角化细胞逐渐失去其细胞体积，最终变得薄而板层。小鼠毛球的外根鞘由两层细胞层组成。外层细胞数量由上而上逐渐增多，完整的外层由2~3层组成，在小鼠背部毛囊和鼻窦毛囊中分别有10多层细胞。这些细胞产生许多膜受限的、高电子密度的颗粒或牙骨质，最后向毛管角化。在小鼠和人类中，ORS的最内层细胞(IMC)形成了一个独特的单细胞层，尽管小鼠的IMC要薄得多，含有更少的张力细丝。小鼠IMC胞浆内侧有张力细丝堆积，角质透明质生成，但未见胶原体生成。小鼠内膜细胞在角化的内根鞘细胞变性后开始角化。这些发现表明，无论是小鼠还是人，下毛囊都由IRS层、IMC层和ORS外层组成，尽管这两个物种在每一层的细胞分化方面都有一些形态上的差异。
The dorsal and sinus hair follicles from 7-day-old mice of several strains were ultrastructurally examined to study their cell differentiation. The findings were compared with those in human anagen hair follicles. The keratinized cells in the Henle''s and Huxley''s layers gradually lost their cell volume and finally became thin and lamellar in mice. The outer root sheath (ORS) was composed of two cell layers in the mouse hair bulb. The cells in the outer layer gradually increased in number upwards; the completed outer layer consisted of 2-3, and over 10 cell layers in the mouse dorsal and sinus hair follicles, respectively. These cells produced many membrane-limited, highly electron-dense granules or cementsomes, and finally underwent a keratinization toward the hair canal. The innermost cell (IMC) layer of the ORS formed a unique single-cell layer in mice as well as in humans, although the mouse IMC were much thinner and contained fewer tonofilaments. Accumulation of tonofilaments in the inner side of the cytoplasm and keratohyalin production, but no cementsome production occurred in the mouse IMC. The mouse IMC started to keratinize after the degeneration of the keratinized inner root sheath (IRS) cells. These findings suggest that the lower hair follicle is composed of the IRS layers, the IMC layer, and the outer layer of the ORS in either mice or humans, although there are some morphological differences in cell differentiation in each layer between the two species.