Preparation of 5-substituted 1H-tetrazoles from nitriles in water
Preparation of 5-substituted 1H-tetrazoles from nitriles in water
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DOI：
10.1021/jo010635w
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发表时间：
2001-11-30
影响因子：
3.6
通讯作者：
Sharpless, KB
中科院分区：
文献类型：
--
作者：
Demko, ZP;Sharpless, KB
叠氮化钠与腈加成生成1H-四唑的反应在水中以锌盐为催化剂很容易进行。反应的范围是相当广泛的;各种芳族腈，活化和未活化的烷基腈，取代的乙烯基腈，硫氰酸酯，和氰胺都已被证明是可行的基板，为这个反应。
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.