High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project
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DOI：
10.1093/hmg/ddm335
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发表时间：
2008-02-14
影响因子：
3.5
通讯作者：
Tomoike, Hitonobu
中科院分区：
文献类型：
--
作者：
Kato, Norihiro;Miyata, Toshiyuki;Tomoike, Hitonobu
原发性高血压是最常见、最复杂的疾病之一，其病理生理机制的研究已取得了相当大的进展。在过去的十年中，多个全基因组的连锁分析已经进行了300-900微卫星标记，但没有一个单一的研究已经产生了明确的证据，“主要”高血压易感基因（S）。在这里，我们进行了一个三层，高密度的高血压相关性研究，这是最近才成为可能。对于第1层，我们对188名男性高血压受试者和两个普通人群对照组（每组752名受试者）的基因组中分布的80795个SNP进行基因分型。对于第2层（752名高血压和752名血压正常的受试者），我们选择了一组2676个SNP进行基因分型（比值比>= 1.4，P
Essential hypertension is one of the most common, complex diseases, of which considerable efforts have been made to unravel the pathophysiological mechanisms. Over the last decade, multiple genome-wide linkage analyses have been conducted using 300-900 microsatellite markers but no single study has yielded definitive evidence for 'principal' hypertension susceptibility gene(s). Here, we performed a three-tiered, high-density association study of hypertension, which has been recently made possible. For tier 1, we genotyped 80 795 SNPs distributed throughout the genome in 188 male hypertensive subjects and two general population control groups (752 subjects per group). For tier 2 (752 hypertensive and 752 normotensive subjects), we genotyped a panel of 2676 SNPs selected (odds ratio >= 1.4 and P