Histopathology and ultrastructural pathology of cyprinid herpesvirus II (CyHV-2) infection in gibel carp, Carassius auratus gibelio.
Histopathology and ultrastructural pathology of cyprinid herpesvirus II (CyHV-2) infection in gibel carp, Carassius auratus gibelio.
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DOI：
10.1007/s11859-015-1114-9
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Zeng, L. B.
中科院分区：
文献类型：
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作者：
Jiang Nan, Jiang Nan;Xu Jin, Xu Jin;Zeng, L. B.
鲤疱疹病毒Ⅱ型（CyHV-2）是近年来在我国养殖异育银鲫（Carassius auratus gibelio）中发现的一种高死亡率的病毒。病理组织学表现为急性肝细胞坏死、脾坏死、肾坏死、继发性板层增生伴局灶性坏死。急性坏死性心肌炎和粒细胞在受感染的鱼的心腔内是突出的。此外，在肠道的粘膜下层和粘膜上皮中观察到坏死。肾小球、肠道粘膜下层和粘膜上皮、心肌细胞和神经元水肿。透射电镜下可见脾细胞、肾小球细胞、肾造血组织细胞、鳃上皮细胞和脑细胞胞浆内有包涵体。CyHV-2感染异育银鲫的组织病理学和超微结构病理学表现为脾、肾、鳃和脑组织广泛坏死和胞浆内含物，提示CyHV-2可能主要感染鱼的脾、肾、鳃和脑。
Cyprinid herpesvirus II (CyHV-2) infection is identified in cultured gibel carp, Carassius auratus gibelio, with high mortality in China in recent years. Histological pathology includes acute hepatocellular necrosis, splenic necrosis, kidney necrosis, hyperplasia of the secondary lamellae with focal necrosis. Acute necrotic myocarditis and granulocytes are prominent within the cardiac lumen in infected fish. In addition, necrosis is observed in the submucosa and mucosa epithelium of intestinal tract. Edemas are observed in renal glomerulus, submucosa and mucosa epithelium of intestinal tract, myocardial cells and neurons. Transmission electron microscopy indicates the cytoplasmic inclusions in splenocytes, glomerulus cells and hematopoietic tissue cells of kidney, epithelial cells of gills and brain cells. The histopathology and ultrastructural pathology in CyHV-2 infected gibel carp are characterized with extensive necrosis and cytoplasmic inclusions in spleen, kidney, gill and brain, which suggests that CyHV-2 may mainly infect the spleen, kidney, gill and brain of fish.