Association between age and disease specific mortality in medullary thyroid cancer.
Association between age and disease specific mortality in medullary thyroid cancer.
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DOI：
10.1016/j.amjsurg.2020.09.025
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发表时间：
2021-03
影响因子：
3
通讯作者：
Mathur, Aarti
中科院分区：
文献类型：
--
作者：
Sahli, Zeyad T.;Canner, Joseph K.;Zeiger, Martha A.;Mathur, Aarti
本研究的目的是评估诊断为甲状腺髓样癌（MTC）的成人中年龄与疾病特异性死亡率（DSM）之间的关系。使用监测、流行病学和最终结果（SEER-18）分析按年龄（18-64岁、65-79岁、≥80岁）分层的成人MTC患者。采用多变量考克斯回归分析评估患者人口统计学资料、肿瘤大小、淋巴结状态、转移性疾病和DSM手术范围之间的相关性。在1457例MTC患者中，1008例（69.2%）为年轻人，371例（25.5%）为老年人，78例（5.4%）为超老年人。一个显着较高比例的老年人和超老年人低于推荐的MTC手术。在多变量分析中，老年人和超老年人DSM增加的可能性分别为2.9倍和6.7倍（HR：2.91，95%CI：1.83-4.63; p < 0.001和HR：6.70，95%CI：3.69-12.20; p < 0.001）。手术或淋巴结切除术的范围不影响DSM。年龄增加是MTC患者DSM的独立预测因素。
The aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC). Surveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression. Among 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p < 0.001 and HR: 6.70, 95%CI: 3.69–12.20; p < 0.001). Extent of surgery or lymphadenectomy did not affect DSM. Increased age is an independent predictor of DSM in patients with MTC.
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影响因子：
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