PROSTAGLANDINS IN THE RHEUMATIC DISEASES *
PROSTAGLANDINS IN THE RHEUMATIC DISEASES *
复制标题
前列腺素在风湿性疾病中的作用*
DOI：
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发表时间：
1975
影响因子：
5.2
通讯作者：
L. Levine
中科院分区：
文献类型：
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作者：
D. Robinson;M. McGuire;L. Levine
胡枝子素可能通过作为炎症介质和促进骨吸收而参与炎性风湿性疾病的发病机制。与用阿司匹林和吲哚美辛治疗的类似患者和骨关节炎患者相比，在患有炎性风湿性疾病的一组患者中，滑液中的PGB（假定由PGE引起）水平升高。风湿性关节炎滑膜在器官培养中产生大量的PGE2。此外，来源于类风湿性滑膜的成纤维细胞系比来自正常滑膜或皮肤的细胞合成更多的PGE和更多的cAMP。类风湿性关节炎滑膜器官培养物的培养液在体外对小鼠颅盖骨具有大量的骨吸收活性。骨吸收可由滑膜产生的PGE2解释，因为将组织与吲哚美辛孵育可抑制超过90%的活性和PG合成，因为它可定量提取到乙醚中，并且因为它与存在的PGE2浓度相关，如通过放射免疫测定法测量的。
The prostaglandins may participate in the pathogenesis of the inflammatory rheumatic diseases by acting as mediators of inflammation and in promoting bone resorption. Levels of PGB (presumed to arise from PGE) in synovial fluids are elevated in the majority of a group of patients with inflammatory rheumatic diseases, as compared to similar patients treated with aspirin and indomethacin and patients with osteoarthritis. Rheumatoid synovium produces large amounts of PGE2 in organ culture. In addition, fibroblast cell lines derived from rheumatoid synovia synthesize more PGE and more cAMP than do cells from normal synovia or skin. The media from rheumatoid synovial organ cultures contain large quantities of bone-resorbing activity toward mouse calvaria in vitro. The bone resorption can be accounted for by PGE2 produced by the synovia, because the activity and PG synthesis are inhibited by more than 90% by incubation of the tissue with indomethacin, because it is quantitatively extractable into ether, and because it bears a relationship to the concentrations of PGE2 present, as measured by radioimmunoassay.