Semantic matching of pictures in schizophrenia: A cross-cultural ERP study
Semantic matching of pictures in schizophrenia: A cross-cultural ERP study
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DOI：
10.1016/0006-3223(95)00352-5
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发表时间：
1996-08-01
影响因子：
10.6
通讯作者：
ValdesSosa, M
中科院分区：
文献类型：
--
作者：
Bobes, MA;Lei, ZX;ValdesSosa, M
在这项研究中，在图片语义匹配任务中将精神分裂症患者的N400与对照组进行了比较。N400差分波形比较对正常对照组和精神分裂症患者的N400潜伏期进行了比较分析，发现精神分裂症患者的N400潜伏期延长，差异波形中的N400波幅降低;然而，只有一致性试验对患者不同这一结果与精神分裂症患者对语境的利用能力差的假设一致，但与精神分裂症患者的联想通常被解除抑制的简单观点不一致，由于N400和听觉P300的幅度不相关，一般的处理缺陷不能解释结果，最后，通过使用图片匹配，N400在古巴和中国精神分裂症患者的跨文化比较是可能的，这表明N400异常在两组中是相似的。
In this study the N400 of schizophrenics was compared with that of control subjects in a picture semantic-matching task. The comparison of N400 difference waveforms (subtraction of event-related potentials of congruent from those of incongruent trials) between control and patients was supplemented by separate analysis for congruent and incongruent trials, The N400 latency was delayed in patients, Also, the amplitude of N400 in the difference waveform was reduced in schizophrenics; however only congruent trials were different for patients (more negative) with respect to controls, This result is consistent with the hypothesis that schizophrenics use context poorly, but inconsistent with simple versions of the idea that associations are generally disinhibited in schizophrenia, Since the amplitudes of N400 and an auditory P300 were not correlated, a general processing deficit does not explain the results, Finally, by using picture matching, a cross-cultural comparison of N400 in schizophrenics from Cuba and China was possible, which indicated that the N400 abnormalities were similar in both groups.