Diurnal rhythms and effects of fasting and refeeding on rat adipose tissue lipoprotein lipase
Diurnal rhythms and effects of fasting and refeeding on rat adipose tissue lipoprotein lipase
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DOI：
10.1152/ajpendo.1996.271.6.e1092
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发表时间：
1996-12-01
影响因子：
5.1
通讯作者：
Olivecrona, T
中科院分区：
文献类型：
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作者：
Bergo, M;Olivecrona, G;Olivecrona, T
脂肪组织中脂蛋白脂酶(LPL)的活性受营养状态变化的调节。我们测量了正常喂养周期、短期禁食和长期禁食以及禁食后再进食期间大鼠脂肪组织中LPL的活性、质量和mRNA水平。LPL活性表现出昼夜节律。夜间和清晨活性最高，下午早些时候降至最低，然后又上升。这些变化与摄食模式相对应。这些增加和/或减少是由于LPL合成速率的变化和翻译后机制的复合。在短期禁食期间，LPL比活性下降到
The activity of lipoprotein lipase (LPL) in adipose tissue is modulated by changes in the nutritional status. We have measured LPL activity, mass, and mRNA levels in rat adipose tissue during normal feeding cycles, during short- and long-term fasting, and during refeeding after fasting. LPL activity displayed a diurnal rhythm. The activity was highest during the night and early morning, decreased to a minimum during the early afternoon, and then increased again. These changes corresponded to the feeding pattern. The increases and/or decreases resulted from changes in LPL synthetic rate compounded by posttranslational mechanisms. During shortterm fasting, LPL specific activity decreased to