Management of glioblastoma in elderly patients.
Management of glioblastoma in elderly patients.
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DOI:
10.1016/j.jns.2017.07.048
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发表时间:
2017-09-15
影响因子:
4.4
通讯作者:
Lukas RV
中科院分区:
文献类型:
--
作者:
Young JS;Chmura SJ;Wainwright DA;Yamini B;Peters KB;Lukas RV
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55 years of age. The median age of diagnosis for patients with GBM is 64 years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population.
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