Management of glioblastoma in elderly patients.

Management of glioblastoma in elderly patients.
复制标题

DOI:
10.1016/j.jns.2017.07.048
复制
发表时间:
2017-09-15
影响因子:
4.4
通讯作者:
Lukas RV
Lukas RV
中科院分区:
医学3区
文献类型:
--
作者:
Young JS;Chmura SJ;Wainwright DA;Yamini B;Peters KB;Lukas RV

文献摘要

参考文献

被引文献

相似文献

胶质母细胞瘤(GBM)是55岁以上成人中最常见的原发性恶性脑肿瘤。GBM患者诊断的中位年龄为64岁,75至85岁患者的发病率增加。由于年龄相关和/或医学共病的频率较高,老年GBM患者的最佳治疗模式仍在不断发展。老年GBM患者历来被排除在大型对照临床试验之外,因为他们持续治疗应答和/或长期良好结局的可能性降低。在这里,我们强调了目前的治疗考虑老年GBM患者的手术,放射治疗和系统的方式,与考虑改善未来的临床结果为这一患者群体。
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55 years of age. The median age of diagnosis for patients with GBM is 64 years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population.
DOI: 10.1002/cncr.24413
发表时间: 2009-08-15
期刊: CANCER
影响因子: 6.2
作者:
Iwamoto, Fabio M.;Cooper, Anna R.;Abrey, Lauren E.
通讯作者: Abrey, Lauren E.
DOI: 10.1016/j.jocn.2014.09.018
发表时间: 2015-03-01
影响因子: 2
作者:
Kim, Hong Rye;Kim, Kyung Hwan;Lee, Jung-Il
通讯作者: Lee, Jung-Il
DOI: 10.1093/neuonc/nou349
发表时间: 2015-06-01
期刊: NEURO-ONCOLOGY
影响因子: 15.9
作者:
Almenawer, Saleh A.;Badhiwala, Jetan H.;Murty, Naresh K.
通讯作者: Murty, Naresh K.
DOI: 10.1158/1078-0432.ccr-0841-3
发表时间: 2004-01-01
影响因子: 11.5
作者:
Batchelor, TT;Betensky, RA;Louis, DN
通讯作者: Louis, DN
DOI: 10.1056/nejmoa043331
发表时间: 2005-03-10
影响因子: 158.5
作者:
Hegi, ME;Diserens, A;Stupp, R
通讯作者: Stupp, R