EP2 and EP4 prostanoid receptor signaling
EP2 and EP4 prostanoid receptor signaling
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DOI：
10.1016/j.lfs.2003.09.031
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发表时间：
2003-12-05
期刊：
影响因子：
6.1
通讯作者：
Regan, JW
中科院分区：
文献类型：
--
作者：
Regan, JW
EP2和EP4前列腺素受体是前列腺素E-2(PGE(2))四种受体亚型中的两种。它们属于G蛋白偶联受体家族，两种受体最初的特征都是偶联Gs并增加细胞内cAMP的形成。然而，最近我们发现这两种受体都能刺激T细胞因子(Tcf)介导的转录活性。EP2受体主要通过cAMP依赖的蛋白激酶(PKA)起作用，而EP4则利用磷脂酰肌醇3-激酶(PI3K)和PKA。此外，我们还发现EP4受体，而不是EP2，可以通过PI3K途径激活细胞外信号调节激酶(ERKs)I和2，从而诱导早期生长反应因子-1(EGR-1)，这是一种传统上与伤口愈合相关的转录因子。这种对EGR-1表达的诱导对于PGE(2)在癌症和炎症性疾病中的潜在作用具有重要的意义。(C)2003 Elsevier Inc.保留所有权利。
The EP2 and EP4 prostanoid receptors are two of the four subtypes of receptors for prostaglandin E-2 (PGE(2)). They are in the family of G-protein coupled receptors and both receptors were initially characterized as coupling to Gs and increasing intracellular cAMP formation. Recently, however, we have shown that both receptors can stimulate T-cell factor (Tcf) mediated transcriptional activity. The EP2 receptor does this primarily through cAMP-dependent protein kinase (PKA), whereas the EP4 utilizes phosphatidylinositol 3-kinase (PI3K) as well as PKA. In addition, we have shown that the EP4 receptor, but not the EP2, can activate the extracellular signal-regulated kinases (ERKs) I and 2 by way of PI3K leading to the induction of early growth response factor-1 (EGR-1), a transcription factor traditionally associated with wound healing. This induction of EGR-1 expression has significant implications concerning the potential role of PGE(2) in cancer and inflammatory disorders. (C) 2003 Elsevier Inc. All rights reserved.