The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function.
The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function.
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DOI：
10.1016/j.biomaterials.2006.08.041
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发表时间：
2007
期刊：
影响因子：
14
通讯作者：
D. Schmidt;W. J. Kao
中科院分区：
文献类型：
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作者：
D. Schmidt;W. J. Kao
巨噬细胞在介导宿主对生物材料的反应中起关键作用，可能最显著的是通过释放炎性分子如细胞因子白细胞介素-1（IL-1）来引导宿主炎症反应。与生物材料表面相互作用后巨噬细胞反应的程度对器械有效性有很大贡献，但这种相互作用的分子机制仍不清楚。细胞外基质（ECM）蛋白纤连蛋白（FN）被巨噬细胞识别，并经常用于生物材料修饰，以引起更大的细胞粘附和组织整合。巨噬细胞与生物材料表面上的FN和其他ECM分子的相互作用已被证明可诱导多种炎症反应，因此FN和IL-1均可用作模型分子以更好地理解材料介导的巨噬细胞反应的机制。本文综述了过去和目前的研究IL-1，FN和FN衍生物在确定生物材料调节的巨噬细胞功能的相互作用的全面调查。
Macrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function.