Lead exposure and rate of change in cognitive function in older women
Lead exposure and rate of change in cognitive function in older women
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DOI：
10.1016/j.envres.2013.12.010
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发表时间：
2014-02-01
影响因子：
8.3
通讯作者：
Weisskopf, Marc G.
中科院分区：
文献类型：
--
作者：
Power, Melinda C.;Korrick, Susan;Weisskopf, Marc G.
背景：较高的长期累积铅暴露预示着老年男性认知能力下降更快，但缺乏与女性相关的证据。目的：确定铅暴露与女性认知能力下降之间是否存在关联。方法：本研究考虑了584名来自护士健康研究的女性样本，她们住在马萨诸塞州波士顿或附近。我们使用1993-2004年评估的铅暴露生物标志物来量化铅暴露，并通过1995-2008年完成的一系列主要评估学习、记忆、执行功能和注意力的电话认知测试来评估认知能力下降。所有的认知测试分数都进行了z转换以用于分析。我们使用随机效应的线性混合模型来量化每种主要生物标志物与整体认知变化和每个单独测试之间的关联。结果：考虑到个体测试表明，随着胫骨铅浓度的增加，故事记忆和类别流畅性的认知能力下降更大，这是一种长期累积暴露的测量。尽管置信区间包括零值（0.024标准单位，95%置信区间：-0.053,0.004 -相当于年龄增加0.33岁的额外功能下降），但胫骨铅浓度每SD增加的总体认知测试z分数的估计超额年度下降是有暗示意义的。我们发现很少支持认知能力下降与髌骨或血铅之间的联系，这提供了在较短时间内暴露的综合测量。结论：至少在某些认知领域，长期累积铅暴露可能与社区妇女认知能力下降的加速有微弱关联。(C) 2014爱思唯尔公司版权所有。
Background: Higher long-term cumulative lead exposure predicts faster cognitive decline in older men, but evidence of an association in women is lacking. Objective: To determine if there is an association between lead exposure and cognitive decline in women.Methods: This study considers a sample of 584 women from the Nurses' Health Study who live in or near Boston, Massachusetts. We quantified lead exposure using biomarkers of lead exposure assessed in 1993-2004 and evaluated cognitive decline by repeated performance on a telephone battery of cognitive tests primarily assessing learning, memory, executive function, and attention completed in 1995-2008. All cognitive test scores were z-transformed for use in analyses. We used linear mixed models with random effects to quantify the association between each lead biomarker and change in cognition overall and on each individual test.Results: Consideration of individual tests showed greater cognitive decline with increased tibia lead concentrations, a measure of long-term cumulative exposure, for story memory and category fluency. The estimated excess annual decline in overall cognitive test z-score per SD increase in tibia bone lead concentration was suggestive, although the confidence intervals included the null (0.024 standard units, 95% confidence interval: -0.053, 0.004 - an additional decline in function equivalent to being 0.33 years older). We found little support for associations between cognitive decline and patella or blood lead, which provide integrated measures of exposure over shorter timeframes.Conclusions: Long-term cumulative lead exposure may be weakly associated with faster cognitive decline in community-dwelling women, at least in some cognitive domains. (C) 2014 Elsevier Inc. All rights reserved.