PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma
PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma
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DOI：
10.1007/s00109-023-02313-8
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发表时间：
2023-05-01
影响因子：
4.7
通讯作者：
Wang，Xin
中科院分区：
文献类型：
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作者：
Zhang，Xin;Han，Yang;Wang，Xin
套细胞淋巴瘤（MCL）是非霍奇金淋巴瘤的一个亚型，具有高度异质性的临床过程。配对框5（PAX 5）是B细胞分化和生长的调节因子，在几种类型的癌症中异常表达。本文通过对82例MCL患者的临床特征和实验室检查资料进行综合分析，探讨PAX 5在MCL预后中的价值。PAX 5阳性与较短的总生存期（OS;p= 0.011）相关，并被确定为MCL患者的独立预后因素。β2-MG升高（p= 0.027）和晚期套细胞淋巴瘤国际预后指数（MIPI）评分（p= 0.014）与PAX 5阳性表达相关。建立了MIPI-SP风险评分系统，其曲线下面积（AUC）为0.770（95%CI，0.658-0.881），对OS具有上级预后价值。PAX 5相关基因的生物信息学分析支持PAX 5在MCL中的机制作用。本研究为PAX 5在MCL中的潜在作用提供了新的见解，新的风险评分系统MIPI-SP优化了MCL患者的风险分层，并有助于预后评估。关键信息· Paired-box 5阳性表明套细胞淋巴瘤患者预后不良。·MCL患者PAX 5阳性表达与MIPI评分和β2-MG相关。MIPI-SPrisk评分系统对MCL的预后价值上级MIPI评分。
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma with highly heterogeneous clinical courses. Paired-box 5 (PAX5), the regulator of B cell differentiation and growth, is abnormally expressed in several types of cancers. Herein, we explored the prognostic value of PAX5 in MCL by comprehensively analyzing the clinical features and laboratory data of 82 MCL cases. PAX5 positivity was associated with shorter overall survival (OS;p= 0.011) and was identified as an independent prognostic factor in MCL patients. The elevated β2-MG (p= 0.027) and advanced Mantle Cell Lymphoma International Prognostic Index (MIPI) score (p= 0.014) were related to positive PAX5 expression. TheMIPI-SPrisk scoring system was established and exhibited a superior prognostic value for OS depending on an area under the curve (AUC) of 0.770 (95% CI, 0.658–0.881) than MIPI score. Bioinformatic analysis of PAX5-related genes supported the mechanistic roles of PAX5 in MCL. This study provides insight into the potential role of PAX5 in MCL, and the novel risk scoring systemMIPI-SPoptimizes the risk stratification and facilitates prognosis evaluation in MCL patients.Key messages• Paired-box 5 positivity indicated adverse prognosis in mantle cell lymphoma patients.• Positive PAX5 expression was related to MIPI score and β2-MG in MCL patients.•MIPI-SPrisk scoring system has superior prognostic value than MIPI score in MCL.