Long-term storage of an associative memory trace in the cerebellum
Long-term storage of an associative memory trace in the cerebellum
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DOI：
10.1037/0735-7044.119.2.526
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Thompson, RF
中科院分区：
文献类型：
--
作者：
Christian, KM;Thompson, RF
不同的神经区域可能在获得和维持某些记忆的过程中参与。在眨眼反应的延迟经典条件反射中，小脑对于条件反应（CR）的获得和表达是必要的，但长期记忆存储的位点尚不清楚。家兔（Oryctolagus cuniculus）接受训练，过度训练，并给予30天的额外训练或30天的休息。其余组中有一半的受试者接受了提醒训练。然后，受试者接受可逆性失活小脑间位核（蝇蕈醇）或永久性电解损伤。在所有病例中，间位肌的失活和病变完全消除了CR。间位核中记忆形成的部位似乎也是长期记忆储存的部位。
Distinct neural regions may be engaged during acquisition and maintenance of some memories. In delay classical conditioning of the eyeblink response, the cerebellum is necessary for acquisition and expression of the conditioned response (CR), but loci of long-term memory storage are not known. Rabbits (Oryctolagus cuniculus) were trained, overtrained, and given either 30 additional days of training or 30 days of rest. Half the subjects in the rest group were given a reminder training session. Subjects then received either reversible inactivation of the cerebellar interpositus nucleus (muscimol) or permanent electrolytic lesions. In all cases, inactivation and lesions of the interpositus completely abolished the CR. The site of memory formation in the interpositus nucleus also appears to be the site of long-term memory storage.