The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis.
The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis.
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经典的 EDC、邻苯二甲酸酯和有机氯与精子质量异常相关：荟萃分析的系统评价
DOI：
10.1038/srep19982
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发表时间：
2016-01-25
影响因子：
4.6
通讯作者：
Wang SL
中科院分区：
文献类型：
--
作者：
Wang C;Yang L;Wang S;Zhang Z;Yu Y;Wang M;Cromie M;Gao W;Wang SL
由于文献研究结果不一致，内分泌干扰物（EDCs）与人类精子质量之间的关系存在争议，因此，我们进行了一项系统综述和荟萃分析。根据纳入标准进行文献检索和选择，共纳入9项经典EDCs研究（邻苯二甲酸酯类研究5项，有机氯类研究4项），其中7项为横断面研究，1项为病例对照研究，1项为先导研究。漏斗图显示对称分布，没有发表偏倚的证据（Begg检验：截距= 0.40;p = 0.692）。人类精子质量与经典EDCs相关的总比值比（OR）为1.67 （95% CI: 1.31-2.02）。在按特定化学类别分层后，发现邻苯二甲酸酯组（OR = 1.52; 95% CI: 1.09-1.95）和有机氯组（OR = 1.98; 95% CI: 1.34-2.62）精子质量异常的风险一致增加。此外，对官方数据的鉴定和对机制的全面回顾进行了更好地阐明了这些经典EDCs对异常精子质量的风险增加。本系统综述和荟萃分析有助于确定经典EDCs对人类精子质量的影响。然而，它仍然强调需要在更多不同的地理位置进行更多的流行病学研究。
The association between endocrine disrupting chemicals (EDCs) and human sperm quality is controversial due to the inconsistent literature findings, therefore, a systematic review with meta-analysis was performed. Through the literature search and selection based on inclusion criteria, a total of 9 studies (7 cross-sectional, 1 case-control and 1 pilot study) were analyzed for classic EDCs (5 studies for phthalate esters and 4 studies for organochlorines). Funnel plots revealed a symmetrical distribution with no evidence of publication bias (Begg’s test: intercept = 0.40; p = 0.692). The summary odds ratios (OR) of human sperm quality associated with the classic EDCs was 1.67 (95% CI: 1.31–2.02). After stratification by specific chemical class, consistent increases in the risk of abnormal sperm quality were found in phthalate ester group (OR = 1.52; 95% CI: 1.09–1.95) and organochlorine group (OR = 1.98; 95% CI: 1.34–2.62). Additionally, identification of official data and a comprehensive review of the mechanisms were performed and better elucidated the increased risk of these classic EDCs on abnormal sperm quality. The present systematic review and meta-analysis helps to identify the impact of classic EDCs on human sperm quality. However, it still highlights the need for additional epidemiological studies in a larger variety of geographic locations.