Correlation between 3T apparent diffusion coefficient values and grading of invasive breast carcinoma
Correlation between 3T apparent diffusion coefficient values and grading of invasive breast carcinoma
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DOI：
10.1016/j.ejrad.2014.09.015
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发表时间：
2014-12-01
影响因子：
3.3
通讯作者：
de Felice, Carlo
中科院分区：
文献类型：
--
作者：
Cipolla, Valentina;Santucci, Domiziana;de Felice, Carlo
目的：评价3.0T(3T)磁共振弥散加权成像(DWI)提供的表观弥散系数(ADC)是否随浸润性乳腺癌分级的不同而不同。材料与方法：92例患者96个浸润性乳腺癌病变，均行3T磁共振成像(3T)局部分期。所有病变均经组织学证实，并根据Nottingham分级系统(NGS)进行肿瘤分级。MRI包括动态增强序列和DWI序列，并计算每个病变的ADC值。ADC值与NGS分级采用Mann-Whitney U和Kruskal-Wallis H检验进行比较。分级被认为是一个综合预后因素，Rho Spearman检验确定分级与肿瘤大小、激素受体状态、HER2表达和Ki67指数的相关性。结果：G1期肿瘤的ADC值明显高于G3期肿瘤。G1、G3与G2比较，差异无统计学意义。肿瘤大小、激素受体状态、HER2表达和Ki67指数与肿瘤分级显著相关，但只有G3和G1与ER和PR状态、HER2表达和Ki67指数有显著差异。结论：3TDWI的ADC值与低级别(G1)和高级别(G3)浸润性乳腺癌相关。3TADC可能是鉴别高级别浸润性乳腺癌的有用工具。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: The aim of this study was to evaluate whether the apparent diffusion coefficient (ADC) provided by 3.0T (3 T) magnetic resonance diffusion-weighted imaging (DWI) varied according to the grading of invasive breast carcinoma.Materials and methods: A total of 92 patients with 96 invasive breast cancer lesions were enrolled; all had undergone 3 T magnetic resonance imaging (MRI) for local staging. All lesions were confirmed by histological analysis, and tumor grade was established according to the Nottingham Grading System (NGS). MRI included both dynamic contrast-enhanced and DWI sequences, and ADC value was calculated for each lesion. ADC values were compared with NGS classification using the Mann-Whitney U and the Kruskal-Wallis H tests. Grading was considered as a comprehensive prognostic factor, and Rho Spearman test was performed to determine correlation between grading and tumor size, hormonal receptor status, HER2 expression and Ki67 index. Pearson's Chi square test was carried out to compare grading with the other prognostic factors.Results: ADC values were significantly higher in G1 than in G3 tumors. No significant difference was observed when G1 and G3 were compared with G2. Tumor size, hormonal receptor status, HER2 expression and Ki67 index correlated significantly with grading but there was a significant difference only between G1 and G3 related to the ER and PR status, HER2 expression and Ki67 index. There was no statistically significant difference in lesion size between the two groups.Conclusion: ADC values obtained on 3 T DWI correlated with low-grade (G1) and high-grade ( G3) invasive breast carcinoma. 3 T ADC may be a helpful tool for identifying high-grade invasive breast carcinoma. (C) 2014 Elsevier Ireland Ltd. All rights reserved.