Synthesis of 3′,5′-cyclic diguanylic acid (cdiGMP) using 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl as a protecting group for 2′-hydroxy functions of ribonucleosides
Synthesis of 3′,5′-cyclic diguanylic acid (cdiGMP) using 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl as a protecting group for 2′-hydroxy functions of ribonucleosides
复制标题
DOI：
10.1080/15257770601112762
复制
发表时间：
2007-01-01
影响因子：
1.3
通讯作者：
Aguilar, Aime Lopez
中科院分区：
文献类型：
--
作者：
Yan, Hongbin;Aguilar, Aime Lopez
本文报道了一种用修饰h -膦酸盐法合成3′，5′-环二胍酸的简便方法。采用1-（4-氯苯基）-4-乙氧基辣椒苷-4-基（Cpep）基团作为核糖核苷2′-羟基功能的保护基团。完全解封完全保护的3',5'-环二胍酸使cdiGMP作为一种均相化合物，收率很高。
We herein report a convenient synthesis of 3',5'-cyclic diguanylic acid via the modified H-phosphonate approach. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as Protecting group for the 2'-hydroxy functions of ribonucleosides. Complete unblocking of the fully protected 3',5'-cyclic diguanylic acid gave cdiGMP as a homogeneous compound in an excellent yield.