Adipose tissue stem cells: the great WAT hope.
Adipose tissue stem cells: the great WAT hope.
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DOI：
10.1016/j.tem.2012.01.003
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发表时间：
2012-06
影响因子：
10.9
通讯作者：
MacDougald, Ormond A.
中科院分区：
文献类型：
--
作者：
Cawthorn, William P.;Scheller, Erica L.;MacDougald, Ormond A.
在过去的十年里，脂肪组织干细胞（ASC）的研究出现了爆炸式增长，这是因为它们易于从白色脂肪组织（WAT）中分离出来，并受到其治疗潜力的推动。最近的发展已经将ASC多能性扩展到包括内胚层和外胚层细胞类型，沿着诱导多能干细胞的产生。这种不断扩大的多能性已经被迅速发展的转化应用所取代，从组织工程到抗癌治疗，目前正在进行临床试验。然而，这一承诺受到潜在陷阱的影响，例如致瘤性，并且由于关于ASC身份的不确定性而进一步受到破坏。如果我们要绕过陷阱并发展ASCs的承诺，面对这些问题将是至关重要的。
The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, along with generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the very identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.
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影响因子：
3.7
作者：
Chandra V;Swetha G;Muthyala S;Jaiswal AK;Bellare JR;Nair PD;Bhonde RR
通讯作者：
Bhonde RR
DOI：
10.1093/ndt/gfq603
发表时间：
2010-12
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Feng Z;Ting J;Alfonso Z;Strem BM;Fraser JK;Rutenberg J;Kuo HC;Pinkernell K
通讯作者：
Pinkernell K
影响因子：
37.8
作者：
Gealekman O;Guseva N;Hartigan C;Apotheker S;Gorgoglione M;Gurav K;Tran KV;Straubhaar J;Nicoloro S;Czech MP;Thompson M;Perugini RA;Corvera S
通讯作者：
Corvera S
影响因子：
4.1
作者：
Casteilla, Louis;Planat-Benard, Valerie;Cousin, Beatrice
通讯作者：
Cousin, Beatrice
影响因子：
--
作者：
Gonzalez, Manuel A.;Gonzalez-Rey, Elena;Delgado, Mario
通讯作者：
Delgado, Mario