Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure-activity relationship (SAR)
Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure-activity relationship (SAR)
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DOI：
10.1016/j.bmc.2011.06.023
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发表时间：
2011-08-15
影响因子：
3.5
通讯作者：
Rodrigues, Carlos Rangel
中科院分区：
文献类型：
--
作者：
Bello, Murilo Lamim;Chiaradia, Louise Domeneghini;Rodrigues, Carlos Rangel
在这项工作中，我们描述了一系列查尔酮衍生物的合成、抗利什曼活性以及分子建模和构效关系（SAR）评估。在这些化合物中，甲氧基查尔酮 2h、2i、2j、2k 和 2l 显示出显着的抗利什曼活性（IC50
In this work we described the synthesis, the antileishmanial activity and the molecular modeling and structure-activity relationship (SAR) evaluations of a series of chalcone derivatives. Among these compounds, the methoxychalcones 2h, 2i, 2j, 2k and 2l showed significant antileishmanial activity (IC50