The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.
The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.
复制标题
DOI：
10.3389/fimmu.2020.622468
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
MacIver NJ
中科院分区：
文献类型：
--
作者：
Kiernan K;MacIver NJ
瘦素是对整体营养变化的免疫反应的关键介质。瘦素由脂肪细胞产生，与脂肪组织质量成比例，因此在肥胖症中增加。尽管瘦素在调节全身代谢和食欲方面具有良好的作用，但瘦素显示多效性作用，并且现在清楚的是瘦素在影响免疫细胞功能方面具有关键作用。事实上，许多免疫细胞已被证明直接通过瘦素受体对瘦素作出反应，导致主要的促炎表型。了解脂肪组织源性介质在炎症中的作用对于确定多种肥胖相关疾病（如2型糖尿病、自身免疫性疾病和感染）的病理生理学至关重要。因此，本文综述了瘦素在调节炎症中的作用的最新数据。
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.