In-utero androgen exposure and 2nd to 4th digit length ratio - comparisons between healthy controls and females with classical congenital adrenal hyperplasia
In-utero androgen exposure and 2nd to 4th digit length ratio - comparisons between healthy controls and females with classical congenital adrenal hyperplasia
复制标题
DOI：
10.1093/humrep/deg198
复制
发表时间：
2003-05-01
影响因子：
6.1
通讯作者：
Acerini, CL
中科院分区：
文献类型：
--
作者：
Buck, JJ;Williams, RM;Acerini, CL
背景：手部软组织测量显示，与女性相比，男性第二指与第四指的手指比例（2D：4D）较低。在男性中观察到的相对较长的第四根手指可能与胎儿暴露于影响 Hox 基因表达的雄激素的增加有关。方法：我们测量了 69 名健康女性[中位年龄 9.3（范围 1.9-17）岁]、77 名对照男性[中位年龄 13.86（2.1-20.3）岁]和 66 名患有典型男性化先天性肾上腺增生症 (CAH) 的女性（中位年龄 8.5（1.1-16.2）岁）的 2D:4D 比率。已知在子宫内暴露于高浓度雄激素的患者使用游标卡尺通过左手 X 射线进行测量，观察者内的变异性为 0.01% 结果：与女性患者相比，对照男性的平均 (SD) 2D:4D 比率 [0.918 (0.029)，ANOVA P =。 CAH 女性 [0.925 (0.021)] 和对照女性 [0.927 (0.029)] 之间的 2D:4D 比率没有观察到差异，相比之下，男性 2D:4D 比率显着低于 CAH 女性 (P = 0.03)：直接从左手 X 线照片确定的 2D:4D 比率证实了两者之间的显着差异。然而，患有男性化 CAH 的女性患者没有男性的手指比例模式，这表明左手手指比例的发育不受子宫内雄激素暴露的影响。
BACKGROUND: Soft tissue measurements from the hand reveal lower second to fourth finger digit ratios (2D:4D) in males compared with females. The relatively longer 4th finger observed in males may be related to increased fetal exposure to androgens influencing the expression of Hox genes. METHODS: We have measured 2D:4D ratios in 69 healthy females [median age 9.3 (range 1.9-17) years], 77 control males [median age 13.86 (2.1-20.3) years] and in 66 females with classical virilizing congenital adrenal hyperplasia (CAH) (median age 8.5 (1.1-16.2) years] who are known to be exposed to high concentrations of androgens in utero. Measurements were determined from X-rays of the left hand using vernier callipers. Intra-observer variability in measurement technique was 0.01%. RESULTS: Control males had a significantly lower mean (SD) 2D:4D ratio [0.918 (0.029)] compared with female patients [0.927 (0.029), ANOVA P = 0.02]. No difference in 2D:4D ratio was observed between CAH females [0.925 (0.021)] and control females [0.927 (0.029)]. In contrast, 2D:4D ratio in males were significantly lower compared with CAH females (P = 0.03). CONCLUSIONS: 2D:4D ratios determined directly from radiographs of the left hand confirm significant differences between males and females. However, female patients with virilizing CAH do not have a male digit ratio pattern suggesting that in the left hand digit ratio development is not influenced by in-utero exposure to androgens.