The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity.
The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity.
复制标题
DOI：
10.1126/science.2580348
复制
发表时间：
1985-04
期刊：
影响因子：
56.9
通讯作者：
C. W. Rettenmier;J. H. Chen;M. Roussel;C. Sherr
中科院分区：
文献类型：
--
作者：
C. W. Rettenmier;J. H. Chen;M. Roussel;C. Sherr
C-fms原癌基因是与肿瘤发生有关的基因家族中的一员。用抗v-FMS编码表位的单抗进行免疫复合激酶分析，鉴定了猫脾细胞中c-FMS编码的糖蛋白。正常细胞糖蛋白的主要形式表观分子量为17万，与病毒癌基因的产物一样，在体外作为相关酪氨酸特异性蛋白激酶活性的底物。结果表明，v-FMS特异的转化糖蛋白是c-FMS编码的生长因子受体的截短形式。
The c-fms proto-oncogene is a member of a gene family that has been implicated in tumorigenesis. Glycoproteins encoded by c-fms were identified in cat spleen cells by means of an immune-complex kinase assay performed with monoclonal antibodies to v-fms-coded epitopes. The major form of the normal cellular glycoprotein has an apparent molecular weight of 170,000 and, like the product of the viral oncogene, serves as a substrate for an associated tyrosine-specific protein kinase activity in vitro. The results suggest that the transforming glycoprotein specified by v-fms is a truncated form of a c-fms-coded growth factor receptor.