Convergence between Lesion-Symptom Mapping and Functional Magnetic Resonance Imaging of Spatially Selective Attention in the Intact Brain
Convergence between Lesion-Symptom Mapping and Functional Magnetic Resonance Imaging of Spatially Selective Attention in the Intact Brain
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完整大脑空间选择性注意力的病变症状映射与功能磁共振成像之间的收敛
DOI：
--
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发表时间：
2008
影响因子：
5.3
通讯作者：
R. Vandenberghe
中科院分区：
文献类型：
--
作者：
P. Molenberghs;C. Gillebert;R. Peeters;R. Vandenberghe
顶叶区域涉及空间选择性注意力的患者病变的研究和完整的大脑功能成像之间的差异。我们的目标是解决这种不一致。在20例缺血性卒中患者的基于体素的病变-症状映射研究中，我们采用了与23名健康志愿者相同的认知减法方法，这些志愿者使用相同的任务和刺激进行功能性磁共振成像（fMRI）。一个指导性的中央线索将注意力引导到一个视觉象限。在短暂的延迟之后，光栅出现在该象限中，并且在未提示的象限中出现不相关的光栅。受试者必须辨别提示象限中光栅的方向。患者与右下顶叶病变的contralesional与同病灶定向时，刺激是双边和对称的，比当刺激占据对角相反的象限或两个象限内相同的半野显着受损。在一个区域，病变体积图与健康志愿者的活动图重叠：右顶内沟（IPS）中间三分之一的下岸。在另外37名健康的fMRI受试者中，我们解开了刺激之间的对称性，双侧性和空间配置对重叠量活动的影响。只有刺激之间的配置轴有显着的效果，最高的活动时，配置轴是水平的。这构成了来自患者和认知完整受试者的汇聚证据，即右侧IPS的中间三分之一的下岸以空间各向异性的方式对竞争刺激之间的注意选择做出了重要贡献。
The parietal regions implicated in spatially selective attention differ between patient lesion studies and functional imaging of the intact brain. We aimed to resolve this discordance. In a voxel-based lesion-symptom mapping study in 20 ischemic stroke patients, we applied the same cognitive subtraction approach as in 23 healthy volunteers who underwent functional magnetic resonance imaging (fMRI) using identical tasks and stimuli. An instructive central cue directed attention to one visual quadrant. After a brief delay, a grating appeared in that quadrant together with an irrelevant grating in an uncued quadrant. Subjects had to discriminate the orientation of the grating in the cued quadrant. Patients with a right inferior parietal lesion were significantly more impaired during contralesional versus ipsilesional orienting when stimuli were bilateral and symmetrical than when stimuli occupied diagonally opposite quadrants or two quadrants within the same hemifield. In one area, the lesion-volume map overlapped with the activity map obtained in healthy volunteers: the lower bank of the middle third of the right intraparietal sulcus (IPS). In an additional 37 healthy fMRI subjects, we disentangled the effects of symmetry, bilaterality, and spatial configuration between stimuli on activity in the volume of overlap. Only the axis of configuration between stimuli had a significant effect, with highest activity when the configuration axis was horizontal. This constitutes converging evidence from patients and cognitively intact subjects that the lower bank of the middle third of the right IPS critically contributes to attentive selection between competing stimuli in a spatially anisotropic manner.
影响因子：
3.7
作者：
Molenberghs, Pascal;Mesulam, Marsel M.;Vandenberghe, Rik R. C.
通讯作者：
Vandenberghe, Rik R. C.
右顶叶损伤造成的半侧空间缺陷是否与视网膜或重力坐标相关？
DOI：
10.1093/brain/110.1.167
发表时间：
1987
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ladavas,E
通讯作者：
Ladavas,E
影响因子：
2.5
作者：
Kastner, S;De Weerd, P;Ungerleider, LG
通讯作者：
Ungerleider, LG