Protein adsorption of biomedical polymers influences activated monocytes to produce fibroblast stimulating factors.
Protein adsorption of biomedical polymers influences activated monocytes to produce fibroblast stimulating factors.
复制标题
生物医学聚合物的蛋白质吸附影响活化的单核细胞产生成纤维细胞刺激因子。
DOI：
10.1002/jbm.820260404
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Anderson,JM
中科院分区：
文献类型：
--
作者：
Bonfield,TL;Colton,E;Anderson,JM
The studies presented in this manuscript were based upon the hypothesis that monocytes/macrophages selectively produce cytokines and growth factors due to their interactions with polymers and proteins which are adsorbed to their surfaces. These factors in turn selectively influence the ability of fibroblasts to proliferate. The factors which influence fibroblast proliferation were released from monocytes incubated with polymers: Biomer®, polydimethylsiloxane (PDMS), polyethylene (PE), expanded polytetrafluoroethylene (ePTFE), Dacron, and control polystyrene with and without preadsorption with physiological concentrations of IgG, fibrinogen, fibronectin, hemoglobin, or albumin. No simple correlation was found between adsorbed protein, biomedical polymer, and the ability monocytes to produce growth factors and cytokines which influence fibroblast proliferation. This is evidence for selective protein‐polymer interactions which turn selectively activate monocytes produce variable cell cycle competence and progression factors controlling fibroblast growth.
