Auditory evoked arousal responses of 3-month-old infants exposed to methamphetamine in utero: a nap study.
Auditory evoked arousal responses of 3-month-old infants exposed to methamphetamine in utero: a nap study.
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听觉诱发子宫内接触甲基苯丙胺的 3 个月大婴儿的唤醒反应：一项午睡研究。
DOI：
10.1111/apa.12136
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
NZIDEALStudyGroup
中科院分区：
文献类型：
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作者：
Galland,BarbaraC;Mitchell,EdA;Thompson,JohnMD;Wouldes,Trecia;NZIDEALStudyGroup
目的调查产前接触甲基苯丙胺的婴儿是否会损害睡眠觉醒反应。方法多导睡眠研究涉及42名3个月大的婴儿，他们在子宫内接触甲基苯丙胺，对照组为57名婴儿。在这两组中，都有一部分母亲在怀孕期间吸烟和/或吸食大麻并饮酒。在非快速眼动（NREM）和快速眼动（REM）睡眠状态下，以10 dB的间隔给予50至100分贝（dB）的白色噪声两次，并测量唤醒阈值。（128和178在REM和NREM睡眠，婴儿在REM睡眠中比在NREM睡眠中更可能在较低的阈值下醒来（风险比5.58; 95%CI，3.78 - 8.23 p <0.0001）。在控制其他物质使用之前或之后，甲基苯丙胺和对照组之间的唤醒阈值没有显著差异（NREM睡眠; 0.98，95% CI，0.60 - 1.59和REM睡眠; 1.03，95%CI，0.56 - 1.89）。结论这些发现表明，甲基苯丙胺暴露的婴儿的唤醒反应保持不变，没有提供支持的假设，产前暴露可能会增加他们的脆弱性，婴儿猝死综合症（SIDS）通过唤醒缺陷。
AimTo investigate whether or not infants exposed to methamphetamine prenatally have impaired arousal responses from sleep.MethodsThe polygraphic nap studies involved 42 infants aged 3 months exposed to methamphetaminein uteroand a comparison group of 57 infants. A proportion of mothers in both groups smoked cigarettes and/or marijuana and drank alcohol during pregnancy. White noise from 50 to 100 decibels (dB) was administered at 10 dB intervals twice within non‐rapid eye movement (NREM) and rapid eye movement (REM) sleep states and arousal thresholds measured.ResultsCombining groups, 306 tests were completed (128 and 178 within REM and NREM sleep, respectively) and infants were more likely to wake at lower thresholds in REM than NREM sleep (hazard ratio 5.58; 95% CI, 3.78–8.23 p < 0.0001). No significant differences in arousal threshold were found between methamphetamine and comparison groups, before or after controlling for other substance use (NREM sleep; 0.98, 95% CI, 0.60–1.59 and REM sleep; 1.03, 95% CI, 0.56–1.89).ConclusionsThese findings suggest that arousal responses of methamphetamine‐exposed infants remain intact, providing no support for the hypothesis that prenatal exposure could increase their vulnerability to sudden infant death syndrome (SIDS) through arousal deficits.