New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target
New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target
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DOI：
10.1111/j.1365-2796.2006.01745.x
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发表时间：
2007-01-01
影响因子：
11.1
通讯作者：
Aperia, A.
中科院分区：
文献类型：
--
作者：
Aperia, A.
Na， k - atp酶（NKA）被认为是细胞、器官和全身电解质和液体平衡的维持者。令人兴奋的新发现揭示了NKA作为生长、凋亡、细胞粘附和运动的信号换能器和调节剂的其他基本作用。信号转导功能可通过与哺乳动物类似的洋地黄与NKA结合而触发。NKA的催化亚基以不同的形式存在，在大脑中表达的两种形式的突变可引起偏头痛、癫痫和帕金森样症状。这篇综述将介绍NKA的这些新方面及其临床意义。
Na,K-ATPase (NKA) is well known for its role as a maintainer of electrolyte and fluid balance in cells, organs and whole body. Exciting new findings have revealed additional fundamental roles for NKA as a signal transducer and modulator of growth, apoptosis, cell adhesion and motility. The signal transduction function can be triggered by the binding of ouabain, the mammalian analogue of digitalis to NKA. The catalytic subunit of NKA exists in different forms and mutations in two of the forms that are expressed in brain can give rise to migraine, epilepsy and Parkinsonism - like symptoms. This review will present these new aspects of NKA and their clinical implications.