Bioengineering approaches to study multidrug resistance in tumor cells.
Bioengineering approaches to study multidrug resistance in tumor cells.
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DOI：
10.1039/c0ib00142b
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Zaman MH
中科院分区：
文献类型：
--
作者：
Fallica B;Makin G;Zaman MH
癌细胞对化疗药物产生抗药性的能力是恶性肿瘤治疗面临的主要挑战。已经出现了几种试图抑制化疗耐药性的策略，但事实仍然是，耐药性是每一种有效抗癌药物的问题。本综述的第一部分将集中在化疗耐药的机制上。在我们希望有效地对抗化疗耐药之前，了解与化疗耐药相关的环境线索、运输限制和细胞信号通路是很重要的。本审查的第二部分侧重于今后需要完成的工作。具体地说，这一部分着重于翻译研究和跨学科指导的必要性。至关重要的是，肿瘤学家、生物学家和工程师的专业知识应该聚集在一起，试图解决这个问题。这一讨论是从工程学的角度进行的，因为工程师和其他癌症研究人员之间的对话是最具挑战性的，因为背景知识不重叠。化疗耐药是一个复杂和毁灭性的过程，这意味着我们迫切需要复杂的方法来研究细胞如何变得耐药的过程。
The ability of cancer cells to become resistant to chemotherapeutic agents is a major challenge for the treatment of malignant tumors. Several strategies have emerged to attempt to inhibit chemoresistance, but the fact remains that resistance is a problem for every effective anticancer drug. The first part of this review will focus on the mechanisms of chemoresistance. It is important to understand the environmental cues, transport limitations and the cellular signaling pathways associated with chemoresistance before we can hope to effectively combat it. The second part of this review focuses on the work that needs to be done moving forward. Specifically, this section focuses on the necessity of translational research and interdisciplinary directives. It is critical that the expertise of oncologists, biologists, and engineers be brought together to attempt to tackle the problem. This discussion is from an engineering perspective, as the dialogue between engineers and other cancer researchers is the most challenging due to non-overlapping background knowledge. Chemoresistance is a complex and devastating process, meaning that we urgently need sophisticated methods to study the process of how cells become resistant.
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影响因子：
11.2
作者：
Barone I;Cui Y;Herynk MH;Corona-Rodriguez A;Giordano C;Selever J;Beyer A;Andò S;Fuqua SA
通讯作者：
Fuqua SA
影响因子：
--
作者：
Bhandari, RNB;Riccalton, LA;Shakesheff, KM
通讯作者：
Shakesheff, KM
影响因子：
3.6
作者：
Brown, LM;Cowen, RL;Williams, KJ
通讯作者：
Williams, KJ
影响因子：
3.5
作者：
Dewhirst, MW
通讯作者：
Dewhirst, MW
影响因子：
3.5
作者：
Chakrapani, Harinath;Wilde, Thomas C.;Saavedra, Joseph E.
通讯作者：
Saavedra, Joseph E.