The sodium bile salt cotransport family SLC10
The sodium bile salt cotransport family SLC10
复制标题
DOI：
10.1007/s00424-003-1130-z
复制
发表时间：
2004-02-01
影响因子：
4.5
通讯作者：
Dawson, P
中科院分区：
文献类型：
--
作者：
Hagenbuch, B;Dawson, P
钠/胆盐共转运蛋白SLC 10家族在动物、植物和细菌物种中包含超过50个成员。在人类中，已知有两个特征明确的成员和三个孤儿转运蛋白。Na+/牛磺胆酸盐共转运多肽（NTCP; SLC 10A 1）和顶端钠依赖性胆盐转运蛋白（ASBT; SLC 10A 2）是胆盐肠肝循环的关键组分。NTCP和ASBT是介导钠依赖性的共转运蛋白，主要是胆汁盐进入肝细胞（NTCP）、胆管上皮细胞、回肠肠上皮细胞和肾近端小管细胞（ASBT）的产电摄取。
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).