REGULATION OF pri-miRNA PROCESSING THROUGH Smads
REGULATION OF pri-miRNA PROCESSING THROUGH Smads
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DOI：
10.1007/978-1-4419-7823-3_2
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发表时间：
2010-01-01
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影响因子：
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通讯作者：
Davis, Brandi N.
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文献类型：
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作者：
Hata, Akiko;Davis, Brandi N.
microRNA（miRNAs）是一类小的非编码RNA，通过调节mRNA的稳定性和翻译调控，在多种生物学功能中发挥重要作用。大量的miRNA谱研究表明，在发育阶段和各种病理生理和生理条件下，miRNA的水平受到严格控制。转录后，长的初级miRNA转录物经历一系列协调的成熟步骤以产生成熟的miRNA。然而，控制miRNA生物合成的信号通路和调控机制还不清楚。在本章中，我们将讨论的发现，转化生长因子β（TGF β）信号通路的信号转导，Smads，发挥了关键的调节作用的核处理的miRNA的RNase III型蛋白Drosha。
microRNAs (miRNAs) are small (similar to 22 nucleotides (nt)), noncoding RNAs that play a critical role in diverse biological functions by modulating mRNA stability and translational control. Numerous miRNA profiling studies have indicated that the levels of miRNAs are tightly controlled during developmental stages and various pathophysiological and physiological conditions. Following transcription, the long primary miRNA transcript undergoes a series of coordinated maturation steps to generate the mature miRNA. Signaling pathways that control miRNA biogenesis and the mechanisms of regulation, however, are not well understood. In this chapter, we will discuss the finding that signal transducers of the Transforming Growth Factor beta (TGF beta) signaling pathway, the Smads, play a critical regulatory role in the nuclear processing of miRNAs by the RNase III-type protein Drosha.