Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
复制标题
DOI：
10.1016/j.bbr.2004.05.016
复制
发表时间：
2005-01-06
影响因子：
2.7
通讯作者：
Schröder, N
中科院分区：
文献类型：
--
作者：
de Lima, MNM;Laranja, DC;Schröder, N
本研究旨在探讨阻断NMDA受体对物体再认记忆形成的影响。在第一个实验中，成年Wistar大鼠在进行新的物体识别任务训练前20min，给予生理盐水或NMDA型受体拮抗剂[(+)-5-甲基-10，11-二氢-5H-二苯并-[a，d]环庚烯-5，10-亚胺-马来酸](MK-801)(0.001、0.01或0.1 mg/kg)。实验二：训练结束后立即给予生理盐水或MK-801(0.1 mg/kg)。在训练后1.5小时和24小时测试记忆保持能力。无论是在训练前还是训练后，MK-801都会损害物体识别记忆的短期和长期保持。结果提示，NMDA受体激活是形成物体识别记忆所必需的。(C)2004爱思唯尔B.V.保留所有权利。
The aim of the present study was to investigate the effects of NMDA receptor blockade on formation of object recognition memory. In the first experiment, adult Wistar rats were given an intraperitoneal injection of saline or the NMDA receptor antagonist [(+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclo-hepten-5,10-imine-maleate] (MK-801) (0.001, 0.01, or 0.1 mg/kg) 20 min prior to training in a novel object recognition task. In the second experiment, saline or MK-801 (0.1 mg/kg) were given immediately after training. Memory retention was tested 1.5 and 24 h after training. MK-801 impaired both short- and long-term retention of object recognition memory when given either before or after training. The results suggest that NMDA receptor activation is necessary for formation of object recognition memory. (C) 2004 Elsevier B.V. All rights reserved.