Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.
Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.
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DOI：
10.1097/bor.0000000000000098
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发表时间：
2014-09
影响因子：
5.1
通讯作者：
Gram H
中科院分区：
文献类型：
--
作者：
Nirmala N;Grom A;Gram H
本文综述了全身性幼年特发性关节炎（sJIA）的生物标志物。广义上，标记物被分类为蛋白质、细胞、基因表达和遗传标记物。我们还比较了sJIA中的生物标志物与cryopyrin相关周期性综合征（CAPS）中的生物标志物。最近的出版物显示sJIA和CAPS对抗IL 1治疗的临床反应相似，这促使在生物标志物水平上进行比较。sJIA传统上被分类在幼年特发性关节炎的保护伞下。在临床表型水平上，sJIA有几个特征与Cryopyrin相关周期性Syndrome（CAPS）中观察到的特征更相似。在这篇综述中，我们总结了sJIA和CAPS中的生物标志物，并借鉴了两个疾病家族之间的各种相似性和差异。sJIA和CAPS生物标志物之间的主要差异是遗传标志物，其中CAPS是具有NLRP 3突变的单基因疾病家族。有少量文献描述了sJIA中的细胞生物标志物，但没有描述CAPS的此类研究。sJIA的许多蛋白质标志物特征也被认为是CAPS的特征。sJIA和CAPS中的基因表达数据均显示先天免疫途径的强烈上调。此外，我们描述了sJIA和CAPS在基因表达水平上的强烈相似性，其中形成红细胞生成签名的一部分的几个基因在sJIA和CAPS中都上调。
This review summarizes biomarkers in Systemic Juvenile Idiopathic Arthritis (sJIA). Broadly, the markers are classified under protein, cellular, gene expression and genetic markers. We also compare the biomarkers in sJIA to biomarkers in cryopyrin associated periodic syndromes (CAPS). Recent publications showing the similarity of clinical response of sJIA and CAPS to anti IL1 therapies prompted a comparison at the biomarker level. sJIA traditionally is classified under the umbrella of juvenile idiopathic arthritis. At the clinical phenotypic level, sJIA has several features that are more similar to those seen in Cryopyrin Associated Periodic Syndromes (CAPS). In this review, we summarize biomarkers in sJIA and CAPS and draw upon the various similarities and differences between the two families of diseases. The main difference between sJIA and CAPS biomarkers are genetic markers with CAPS being a family of monogenic diseases with mutations in NLRP3. There have been a small number of publications describing cellular biomarkers in sJIA with no such studies described for CAPS. Many of the protein markers characteristic of sJIA are also seen to characterize CAPS. The gene expression data in both sJIA and CAPS show a strong upregulation of innate immunity pathways. In addition, we describe a strong similarity between sJIA and CAPS at the gene expression level where several genes that form a part of the erythropoiesis signature are upregulated in both sJIA and CAPS.