Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chemically induced toxicity.
Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chemically induced toxicity.
复制标题
呼吸道内异生物质激活和解毒的位点：对化学诱导毒性的影响。
DOI：
10.1016/0041-008x(88)90053-1
复制
发表时间：
1988
影响因子：
3.8
通讯作者：
Voigt,JM
中科院分区：
文献类型：
--
作者：
Baron,J;Burke,JP;Guengerich,FP;Jakoby,WB;Voigt,JM
呼吸道是外源性物质进入体内的主要门户，持续暴露于空气传播的环境化学品以及存在于一般循环中的那些物质。这种接触的一个后果是，该器官系统的不同部分，鼻粘膜、气管和肺，是化学诱导毒性的主要目标。然而，根据米莱尔夫妇（1970、1978、198 1、1982）的开创性研究和许多其他实验室随后的调查，现在很明显，大多数外源性物质本身是无毒的。相反，在暴露于相对惰性的外源性物质后观察到的坏死、诱变、致癌和其他细胞毒性通常被认为是由于这些化学物质形成亲电反应性代谢物（Heidelberger，1975; Mitchell等人，1976; Boyd，1980; Wright，1980;米勒和米勒，1981，1982; Boyd和斯坦森，1983;
The respiratory tract, being a major portal of entry of xenobiotics into the body, is exposed continuously to airborne environmental chemicals as well as to those substances which are present in the general circulation. One consequence of this exposure is that the different segments of this organ system, the nasal mucosa, trachea, and lung, represent major targets for chemically induced toxicity. On the basis of the pioneering studies of the Millers (1970, 1978, 198 1, 1982) and subsequent investigations by numerous other laboratories, it is now apparent, however, that most xenobiotics are not toxic per se. Rather, necrosis, mutagenesis, carcinogenesis, and other cytotoxicities seen after exposure to relatively inert xenobiotics generally are considered to be due to the formation of electrophilically reactive metabolites from these chemicals (Heidelberger, 1975; Mitchell et al., 1976; Boyd, 1980; Wright, 1980; Miller and Miller, 198 1, 1982; Boyd and Statham, 1983;