Cooperative Catalysis by Palladium and a Chiral Phosphoric Acid: Enantioselective Amination of Racemic Allylic Alcohols
Cooperative Catalysis by Palladium and a Chiral Phosphoric Acid: Enantioselective Amination of Racemic Allylic Alcohols
复制标题
DOI：
10.1002/anie.201405511
复制
发表时间：
2014-11-24
影响因子：
16.6
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Banerjee, Debasis;Junge, Kathrin;Beller, Matthias
[Pd（dba）（2）]和手性磷酸BA 1与亚磷酰胺配体L8的协同催化使得外消旋烯丙醇与各种官能化胺的高效对映选择性胺化成为可能。该催化方案是高度区域和立体选择性的（高达e.r. 96：4）并且以几乎定量的产率除去有价值的手性胺。
Cooperative catalysis by [Pd(dba)(2)] and the chiral phosphoric acid BA1 in combination with the phosphoramidite ligand L8 enabled the efficient enantioselective amination of racemic allylic alcohols with a variety of functionalized amines. This catalytic protocol is highly regio- and stereo-selective (up to e.r. 96: 4) and furnishes valuable chiral amines in almost quantitative yield.