Two hundred gastrointestinal stromal tumors - Recurrence patterns and prognostic factors for survival
Two hundred gastrointestinal stromal tumors - Recurrence patterns and prognostic factors for survival
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DOI：
10.1097/00000658-200001000-00008
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发表时间：
2000-01-01
影响因子：
9
通讯作者：
Brennan, MF
中科院分区：
文献类型：
--
作者：
DeMatteo, RP;Lewis, JJ;Brennan, MF
目的回顾性分析200例胃肠道间质瘤（gastrointestinal stromal tumor，GIST）患者的临床资料，并对其进行前瞻性随访。手术切除是治疗的主要手段，因为辅助治疗是unprovided.MethodsTwo百例恶性胃肠道间质瘤患者在过去的16年中，在纪念医院收治和治疗。患者，肿瘤和治疗变量进行了分析，以确定模式的肿瘤复发和预测survival.ResultsOf 200例患者的因素，46%的原发性疾病无转移，47%有转移，7%有孤立的局部复发。在原发性疾病的患者进行了完全切除的大体疾病（n = 80），5年的精算生存率为54%，生存预测肿瘤大小，但不显微镜切缘切除，切除后复发的疾病主要是腹腔内，并涉及原始肿瘤部位，腹膜，liver.ConclusionsGIST是罕见的肉瘤。肿瘤大小可预测接受完整大体切除术的原发病患者的疾病特异性生存率肿瘤复发倾向于腹腔内。研究方案适用于降低切除术后复发率并改善GIST患者的结局。
ObjectiveTo analyze the outcome of 200 patients with gastrointestinal stromal tumor (GIST) who were treated at a single institution and followed up prospectively.Summary Background DataA GIST is a visceral sarcoma that arises from the gastrointestinal tract. Surgical resection is the mainstay of treatment because adjuvant therapy is unproven.MethodsTwo hundred patients with malignant GIST were admitted and treated at Memorial Hospital during the past 16 years. Patient, tumor, and treatment variables were analyzed to identify patterns of tumor recurrence and factors that predict survival.ResultsOf the 200 patients, 46% had primary disease without metastasis, 47% had metastasis, and 7% had isolated local recurrence. In patients with primary disease who underwent complete resection of gross disease (n = 80), the 5-year actuarial survival rate was 54%, and survival was predicted by tumor size but not microscopic margins of resection, Recurrence of disease after resection was predominantly intraabdominal and involved the original tumor site, peritoneum, and liver.ConclusionsGISTs are uncommon sarcomas. Tumor size predicts disease-specific survival in patients with primary disease who undergo complete gross resection. Tumor recurrence tends to be intraabdominal. Investigational protocols are indicated to reduce the rate of recurrence after resection and to improve the outcome for patients with GIST.