Binding of inositol trisphosphate by a liver microsomal fraction.
Binding of inositol trisphosphate by a liver microsomal fraction.
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肌醇三磷酸与肝微粒体部分的结合。
DOI：
10.1042/bj2330929
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Rubin,RP
中科院分区：
文献类型：
--
作者：
Spät,A;Fabiato,A;Rubin,RP
越来越多的证据表明，受体激动剂诱导的胞浆Ca 2+的增加是由肌醇1，4，5-三磷酸介导的，肌醇1，4，5-三磷酸是磷脂酶C介导的磷脂酰肌醇4，5-二磷酸分解的产物。本研究采用肌醇三[32 P]磷酸证明一个特定的受体结合位点在大鼠肝微粒体部分。
Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-trisphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.