The Impact of Individual Mentored Career Development (K) Awards on the Research Trajectories of Early-Career Scientists
The Impact of Individual Mentored Career Development (K) Awards on the Research Trajectories of Early-Career Scientists
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DOI：
10.1097/acm.0000000000002543
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发表时间：
2019-05-01
影响因子：
7.4
通讯作者：
Lund, P. Kay
中科院分区：
文献类型：
--
作者：
Nikaj, Silda;Lund, P. Kay
目的本研究考察了美国国立卫生研究院（NIH）个人指导职业发展奖（K01, K08, K23）在早期职业科学家启动和维持独立研究生涯中的作用，并研究了这些奖项在NIH预算翻倍期间和之后的影响。作者使用了1990年至2016年期间NIH的拨款数据，并比较了K名获奖者和K名未获得资助的申请人获得R01等效奖励（R01 Eq.）和研究项目资助（rpg）的成功情况。分析将回归不连续设计与粗化精确匹配相结合，并结合回归。结果总体而言，获得K奖与获得第一个独立NIH奖的可能性增加24.1%相关（P < 0.01），并且R01 eq和RPG奖的数量增加。在考虑了第一次重大独立研究奖之后，K奖与获得第二次重大独立研究奖不相关。比较不同的资助期，K01奖励在NIH加倍之后但不在NIH加倍期间预测后续的R01 eq和RPG奖励，K08奖励仅在NIH加倍期间预测，K23奖励在两个时期都预测。获得职业发展导师奖与早期职业科学家成功过渡到独立研究职业的可能性增加有关。这些发现表明，向额外的K奖申请人提供资助可以显著加强生物医学研究人员的管道。此外，提高K奖可能与维持临床科学家的研究事业有关。
PurposeThis analysis examined the role of a National Institutes of Health (NIH) individual Mentored Career Development Award (K01, K08, K23) on launching and sustaining independent research careers for early-career scientists, and investigated the effects of these awards during and after the doubling of the NIH budget.MethodThe authors used grants data from the NIH covering the period 1990 through 2016, and compared success in receipt of R01 equivalent awards (R01 Eq.) and Research Project Grants (RPGs) for K awardees and K applicants who did not receive funding. The analysis combined regression discontinuity design with coarsened exact matching, and regression.ResultsOverall, receipt of K award was associated with a 24.1% increase in likelihood of first independent NIH award (P < .01), and a larger number of R01 Eq. and RPG awards. After accounting for first major independent awards, K awards were uncorrelated with receiving second major independent research awards. Comparing different funding periods, K01 awards were predictive of subsequent R01 Eq. and RPG awards after but not during the NIH doubling, K08 awards were predictive only during the NIH doubling, and K23 awards were predictive during both periods.ConclusionsReceipt of Mentored Career Development Awards was linked to increased likelihood that early-career scientists successfully transitioned to an independent research career. These findings indicate that extending funding to additional K award applicants with meritorious scores could significantly strengthen the pipeline of biomedical researchers. In addition, enhancing K awards may be relevant to sustaining research careers for clinician scientists.