Real-world experience with management of spinal ganglioneuroma: long-term follow-up observations of 31 cases.
Real-world experience with management of spinal ganglioneuroma: long-term follow-up observations of 31 cases.
复制标题
脊髓神经节瘤治疗的真实经验：31例长期随访观察。
DOI：
10.1007/s00586-021-06896-z
复制
发表时间：
2021
影响因子：
2.8
通讯作者：
Jianru Xiao
中科院分区：
文献类型：
--
作者：
Haitao Sun;Yao Wang;Xin Jiang;Xiaopan Cai;Ting Wang;Yan Lou;Chenglong Zhao;Zhipeng Wu;Jianru Xiao
脊神经节神经瘤（GN）是起源于神经母细胞的最良性肿瘤。关于脊髓GN的知识很少，因为有零星的病例报道。本研究的目的是描述的临床表现和长期随访结果的脊柱GN后，连续treatment.MethodsThe临床和随访资料的31例脊柱GN接受连续治疗在我院results.ResultsThe平均年龄为40.39 ± 14.8岁。他们被诊断患有脊柱GN，并于2012年2月至2019年8月期间在我院接受手术治疗。其中，22例（71%）患者出现术前神经系统症状。从症状发作到手术的平均时间为19.76 ± 49.59个月。18例患者接受了完整的手术切除，13例患者接受了次全切除。此外，19例患者在经过复杂考虑后同时进行了神经根切断术。平均随访64.13 ± 22.67个月。所有病例术前神经功能障碍在随访期间均明显改善。结论脊柱GN是一种罕见的良性肿瘤，脊柱GN的起源仍有争议。根据我们的经验，我们建议脊髓GN的起源，背根神经节应视为其对应的交感神经节。完全切除是避免恶性事件和复发的首选手术策略。术后密切随访观察。
IntroductionSpinal ganglioneuroma (GN) is the most benign neoplasm of neuroblastic origin. There is little knowledge about spinal GN because of sporadic cases reported. The objective of this study is to describe the clinical manifestations and long-term follow-up outcomes of spinal GN after consecutive treatment.MethodsThe clinical and follow-up data of 31 patients with spinal GN receiving consecutive treatment in our institute are retrospectively analyzed.ResultsThe mean age of the 31 patients was 40.39 ± 14.8 years. They were diagnosed with spinal GN and received surgical treatment in our institution between February 2012 and August 2019. Of them, 22 (71%) patients presented preoperative neurological symptoms. The mean duration from symptom onset to surgery was 19.76 ± 49.59 months. Eighteen patients received complete surgical resection and 13 patients received subtotal excision. In addition, radicotomy was performed simultaneously after sophisticated consideration in 19 patients. The follow-up period averaged 64.13 ± 22.67 months. The preoperative neurological dysfunction was improved significantly during the follow-up period in all cases. No local recurrence or malignant transformation has occurred so far.ConclusionSpinal GN is a rare but benign neoplasm, and the origin of spinal GN remains controversial. With our experience, we propose that the origin of spinal GN from dorsal root ganglion should be equally considered as its counterpart of sympathetic ganglion. Complete resection is the preferred surgical strategy to avoid malignant events and recurrence. And the close postoperative follow-up observations are warranted.