FUSION OF AN IMMUNOGLOBULIN VARIABLE GENE AND A T-CELL RECEPTOR CONSTANT GENE IN THE CHROMOSOME-14 INVERSION ASSOCIATED WITH T-CELL TUMORS
FUSION OF AN IMMUNOGLOBULIN VARIABLE GENE AND A T-CELL RECEPTOR CONSTANT GENE IN THE CHROMOSOME-14 INVERSION ASSOCIATED WITH T-CELL TUMORS
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DOI：
10.1016/0092-8674(85)90243-0
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发表时间：
1985-12-01
期刊：
影响因子：
64.5
通讯作者：
RABBITTS, TH
中科院分区：
文献类型：
--
作者：
BAER, R;CHEN, KC;RABBITTS, TH
在人T细胞肿瘤中经常观察到14号染色体的倒位inv（14）（q11，q32）;细胞遗传学断裂点是令人感兴趣的，因为T细胞受体α-链和免疫球蛋白重链基因分别位于染色体带14 Q11和14 q32上。我们已经研究了α的结构，链基因在T细胞系中携带染色体14倒位。在正常的14号染色体上，V α。片段已与J α非生产性重排。片段相反，倒位染色体的特征是前所未有的重排，其中染色体带14 q32上的免疫球蛋白重链可变基因区段（VH）与J α连接。带14 q11的片段。VH-J α C α重排在基因组水平上是生产性的，因此可以编码杂合免疫球蛋白/T细胞受体多肽。
An inversion of chromosome 14, inv(14)(q11,q32), is frequently observed in human T cells tumors; the cytogenetic breakpoints are of interest because the T cell receptor .alpha.-chain and immunoglobulin heavy chain genes reside on chromosome bands 14Q11 and 14q32, respectively. We have investigated the structure of the .alpha.-chain genes in a T cell line harboring the chromosome 14 inversion. On the normal chromosome 14, a V.alpha. segment has rearranged nonproductively with a J.alpha. segment. In contrast, the inverted chromosome features an unprecedented rearrangement in which an immunoglobulin heavy chain variable gene segment (VH) on chromosome band 14q32 has joined with a J.alpha. segment from band 14q11. The VH-J.alpha.C.alpha. rearrangement is productive at the genomic level and therefore may encode a hybrid immunoglobulin/T cell receptor polypeptide.