NATIONAL GENERAL-PRACTICE STUDY OF EPILEPSY - NEWLY DIAGNOSED EPILEPTIC SEIZURES IN A GENERAL-POPULATION
NATIONAL GENERAL-PRACTICE STUDY OF EPILEPSY - NEWLY DIAGNOSED EPILEPTIC SEIZURES IN A GENERAL-POPULATION
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DOI：
10.1016/0140-6736(90)92959-l
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发表时间：
1990-11-24
期刊：
影响因子：
168.9
通讯作者：
SHORVON, SD
中科院分区：
文献类型：
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作者：
SANDER, JWAS;HART, YM;SHORVON, SD
国家癫痫全科医学研究是一项前瞻性人群队列研究，纳入了1195例新诊断或疑似癫痫发作的患者。在初始分类时（通知后6个月），排除了104例患者。在其余1091例患者中，220例（20% [95%置信区间18-23%]）有热性惊厥，564例（52% [49-55%]）明确癫痫发作，228例（21% [19-23%]）可能癫痫发作。在明确癫痫组中，男性和女性的比例相似，25%（21-28%）小于15岁，24%（21-28%）为60岁或以上。明确的癫痫发作被分类为隐源性62%（58-66%），远程症状性21%（18-25%），急性症状性15%（12-18%）。癫痫的病因是血管疾病，占15%（12-18%），肿瘤占6%（4-8%）。在年龄较大的受试者中，可识别原因的比例要高得多：49%（41-58%）是由于血管疾病，11%（6-16%）是由于肿瘤。在564例明确癫痫发作的患者中，只有252例（45% [41-49%]）在首次发作时登记。52%（48-56%）的患者有部分或继发全身性发作，只有39%（35-43%）的患者从一开始就全身性发作。
The National General Practice Study of Epilepsy is a prospective population-based cohort study of 1195 patients with newly diagnosed or suspected epileptic seizures. At the time of initial classification (6 months after notification), 104 patients were excluded. Of the remaining 1091 patients, 220 (20% [95% confidence interval 18-23%]) had febrile seizures, 564 (52% [49-55%]) definite epileptic seizures, and 228 (21% [19-23%]) possible epilepsy. In the definite epilepsy group the proportions of males and females were similar, 25% (21-28%) were younger than 15 years and 24% (21-28%) were 60 years or older. The definite seizures were classified as cryptogenic in 62% (58-66%), remote symptomatic in 21% (18-25%), and acute symptomatic in 15% (12-18%). The aetiology of epilepsy was vascular disease in 15% (12-18%) and tumour in 6% (4-8%). Among older subjects the proportion with an identifiable cause was much higher: 49% (41-58%) were due to vascular disease and 11% (6-16%) to tumour. Only 252 (45% [41-49%]) of the 564 patients with definite epileptic seizures were registered at the time of their first seizure. 52% (48-56%) of the patients had partial or secondarily generalized seizures, and only 39% (35-43%) seizures generalized from the outset.