The metabolic profiles and body composition of lean metabolic associated fatty liver disease
The metabolic profiles and body composition of lean metabolic associated fatty liver disease
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DOI：
10.1007/s12072-021-10147-0
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发表时间：
2021-02-04
影响因子：
6.6
通讯作者：
Wang, Chia-Chi
中科院分区：
文献类型：
--
作者：
Cheng, Yu-Ming;Kao, Jia-Horng;Wang, Chia-Chi
背景/目的代谢相关脂肪性肝病(MAFLD)是慢性肝病最常见的病因，与肥胖和糖尿病相关。然而，它也发生在苗条的个体中，特别是在亚洲人群中。方法选择慈济MAFLD队列(TCMC)的受试者，包括健康对照组和MAFLD患者。MAFLD的定义是在影像上没有乙肝病毒、丙型肝炎病毒感染、药物、酒精或其他已知原因的慢性肝病的脂肪肝。精瘦受试者(BMI和Lt；23 kg/m(2))将精益MAFLD定义为MAFLD。结果880名受试者进入最终分析。在394例MAFLD患者中，65例(16.5%)被诊断为精瘦MAFLD。瘦身MAFLD患者年龄较大，女性比例较高，ALT、舒张压、甘油三酯和腰围低于非瘦身MAFLD患者，但高密度脂蛋白高于非瘦身MAFLD患者。经二元回归分析，高龄和低腰围与精瘦的MAFLD相关。与消瘦的健康对照组相比，消瘦的MAFLD患者的BMI、腰围和高血压的百分比都更高。在体成分方面，瘦肉型MAFLD患者的脂肪组织指数(FTI)、瘦组织指数(LTI)和总体水量(TBW)均低于非瘦肉型MAFLD患者，但与瘦型健康对照组相当。结论本研究人群中瘦肉型脂肪肝的患病率为16.5%，且在老年人群中患病率较高，尤其是女性人群。瘦肉型MAFLD患者与瘦肉型健康对照组相比具有不同的代谢谱，但与非瘦肉型MAFLD患者相比身体成分不同。
Background/purpose Metabolic associated fatty liver disease (MAFLD) is the commonest cause of chronic liver disease, which is associated with obesity and diabetes. However, it also occurs in lean individuals especially in Asian populations. Methods The participants of Tzu Chi MAFLD cohort (TCMC) including health controls or MAFLD patients were enrolled. MAFLD was defined as fatty liver in imaging without hepatitis B virus, hepatitis C virus infection, drug, alcohol or other known causes of chronic liver disease. Lean MAFLD was defined as MAFLD in lean subjects (BMI < 23 kg/m(2)). Results A total of 880 subjects were included for final analysis. Of 394 MAFLD patients, 65 (16.5%) patients were diagnosed as lean MAFLD. Lean MAFLD patients were elder, higher percentage of female gender, lower ALT, diastolic blood pressure, triglyceride, and waist circumference but higher HDL than non-lean MAFLD patients. Using binary regression analysis, elder age and lower waist circumference were associated with lean MAFLD. Compared with lean healthy controls, lean MAFLD patients had higher BMI, waist circumference, and percentage of hypertension. In body composition, fatty tissue index (FTI), lean tissue index (LTI) ,and total body water (TBW) were lower in lean MAFLD than non-lean MAFLD patients; but they were comparable with lean healthy controls. Conclusions The prevalence of lean MAFLD was 16.5% in this study population and it was higher in elder age, especially of female subjects. Lean MAFLD patients had different metabolic profiles compared with lean healthy controls, but different body composition compared with non-lean MAFLD patients.