Acute heat stress and thermal acclimation induce CCAAT/enhancer-binding protein delta in the goby Gillichthysmirabilis
Acute heat stress and thermal acclimation induce CCAAT/enhancer-binding protein delta in the goby Gillichthysmirabilis
复制标题
急性热应激和热适应诱导虾虎鱼中的CCAAT/增强子结合蛋白δ
DOI：
10.1007/s00360-011-0572-4
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
B. A. Buckley
中科院分区：
文献类型：
--
作者：
B. A. Buckley
CCAAT/增强子结合蛋白（C/EBP）家族转录因子的成员对与细胞命运决定相关的许多过程具有调节控制，包括分化、增殖、细胞周期停滞和凋亡。在哺乳动物中，C/EBP的某些同种型的表达异常是致病性的，并且涉及骨髓性白血病和乳腺癌。几乎没有人知道它们在变温动物中的调节、功能或应激反应。本文研究了急性热应激和热适应诱导宽温性河口虾虎鱼肝脏、白色肌肉和鳃中C/EBP-δ的表达。C/EBP-δ在其他脊椎动物中引起细胞周期停滞和/或促进细胞凋亡的既定作用表明，该蛋白在变温动物中的热诱导作用可能是保守的细胞应激反应的一部分，其假设作用是在环境应激发作期间引起细胞生长的暂时停止和/或程序性细胞死亡。在高温期间观察到的c/ebp-δ的调节代表了鱼类中一种新的热诱导信号通路。
Members of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors have regulatory control over numerous processes related to cell fate determination, including differentiation, proliferation, cell cycle arrest and apoptosis. In mammals, abnormalities in the expression of some isoforms of C/EBPs are pathogenic and are implicated as being involved in myeloid leukemia and breast cancers. Next to nothing is known about their regulation, function or stress-responsiveness in poikilotherms. Here, both acute heat stress and thermal acclimation were demonstrated to induce the expression of one isoform, C/EBP-δ, in the liver, white muscle and gill of the eurythermal estuarine goby, Gillichthys mirabilis. The established role of C/EBP-δ in causing cell cycle arrest and/or promoting apoptosis in other vertebrates suggests that the heat-inducibility of this protein in poikilotherms may be part of the conserved cellular stress response with the hypothesized role of causing temporary cessation of cell growth and/or programmed cell death during bouts of environmental stress. The observed regulation of c/ebp-δ during hyperthermia represents a novel, heat-inducible signaling pathway in fishes.
影响因子：
4
作者：
G. S. Sivko;J. Dewille
通讯作者：
G. S. Sivko;J. Dewille
影响因子：
4
作者：
G. S. Sivko;D. Sanford;L. D. Dearth;D. Tang;J. Dewille
通讯作者：
G. S. Sivko;D. Sanford;L. D. Dearth;D. Tang;J. Dewille
DOI：
10.1006/bbrc.1998.9840
发表时间：
1999-01-08
影响因子：
3.1
作者：
Kim, D;Kim, SH;Li, GC
通讯作者：
Li, GC