Scroll Waves in 3D Virtual Human Atria: A Computational Study
Scroll Waves in 3D Virtual Human Atria: A Computational Study
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3D 虚拟人体心房中的滚动波：计算研究
DOI：
10.1007/978-3-540-72907-5_14
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Henggui Zhang
中科院分区：
文献类型：
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作者：
S. Kharche;G. Seemann;J. Leng;A. Holden;C. Garratt;Henggui Zhang
心房颤动（AF）诱导的离子通道电重构缩短了动作电位时程并降低了心房兴奋性。本文将两项关于心房肌细胞房颤诱发电重构（AFER）的实验数据与人心房细胞计算机模型相结合，模拟其对心房电行为的影响。研究了在正常和AF条件下，人体心房解剖学三维均匀模型中激励涡卷波的动力学行为。在控制条件下，涡卷波在大范围内蜿蜒，并在被解剖障碍物俘获时变得持续。在这种情况下，母转子主导心房兴奋。几个部位的动作电位表现为心房快速起搏。在AF条件下，AFER通过减少弯曲来增加重入涡卷波的稳定性。涡卷波打破导致小波支撑持续的慢性AF。我们的模拟结果支持的假设，AF诱导的电重构永存和维持AF。
Atrial fibrillation (AF) induced electrical remodelling of ionic channels shortens action potential duration and reduces atrial excitability. Experimental data of AF-induced electrical remodelling (AFER) from two previous studies on human atrial myocytes were incorporated into a human atrial cell computer model to simulate their effects on atrial electrical behaviour. The dynamical behaviors of excitation scroll waves in an anatomical 3D homogenous model of human atria were studied for control and AF conditions. Under control condition, scroll waves meandered in large area and became persistent when entrapped by anatomical obstacles. In this case, a mother rotor dominated atrial excitation. Action potentials from several sites behaved as if the atrium were paced rapidly. Under AF conditions, AFER increased the stability of re-entrant scroll waves by reducing meander. Scroll wave break up leads to wavelets underpinning sustained chronic AF. Our simulation results support the hypothesis that AF-induced electrical remodelling perpetuates and sustains AF.