Treatment of Postischemic Reperfusion Cardiac Injury with a Perfluorochemical Solution
Treatment of Postischemic Reperfusion Cardiac Injury with a Perfluorochemical Solution
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全氟化合物溶液治疗缺血再灌注心脏损伤
DOI：
10.1097/00005344-198401000-00024
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发表时间：
1984
影响因子：
3
通讯作者：
R. Boucek
中科院分区：
文献类型：
--
作者：
M. Parrish;R. Olson;P. Mushlin;M. Artman;R. Boucek
在全脑缺血心脏模型中，我们评估了全氟化学溶液对再灌注损伤的影响。以恒定流量逆行灌流的离体兔心脏作为实验模型。在初始全血灌流后，心脏暴露于常温全血缺血30min。然后用全血或20%全氟化学溶液(FC-43)开始再灌注。再灌流120min后，全氟化学灌流心脏的收缩功能恢复(85±5%的基础压力)明显高于血液再灌流的心脏(57±3%的基础压力)。这种功能的恢复只需1小时的全氟化学再灌流，并且在恢复血液灌流时不会丢失。功能恢复的改善不能归因于全氟化学灌流液的化学成分、携氧能力、pH或温度。全氟化合物的有益效果也不可能与左心室静息压的差异有关。我们推测，由于全氟化学溶液和血液再灌流过程中冠脉阻力的显著差异，心功能恢复的改善与全氟化学物质优越的流变性有关。
We assessed the effects of a perfluorochemical solution on reperfusion injury in a globally ischemic heart model. An isolated rabbit heart, retrogradely perfused at a constant flow rate, served as our experimental model. After initial perfusion with whole blood, hearts were exposed to 30 min of normothermic global ischemia. Reperfusion was then begun with either whole blood or a 20% perfluorochemical solution (FC-43). After 120 min of reperfusion, a markedly greater recovery of contractile function was observed in the perfluorochemical-reperfused hearts (85 ± 5% of baseline developed pressure) compared with blood-reperfused hearts (57 ± 3% of baseline developed pressure). This recovery of function was accomplished with only 1 h of perfluorochemical reperfusion and was not lost on returning to blood perfusion. The improved recovery of function could not be attributed to the chemical composition, oxygen-carrying capacity, pH, or temperature of the perfluorochemical perfusate. Neither could the beneficial effects of perfluorochemical be related to differences in left ventricular resting pressure. We speculate that, because of marked differences in coronary resistance during reperfusion with perfluorochemical solution and blood, improved recovery of cardiac function is related to the superior rheological properties of perfluorochemicals.