Non-coding RNAs in Uterine Development, Function and Disease.
Non-coding RNAs in Uterine Development, Function and Disease.
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DOI：
10.1007/978-94-017-7417-8_9
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发表时间：
2016
影响因子：
--
通讯作者：
Nothnick WB
中科院分区：
文献类型：
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作者：
Nothnick WB
子宫的主要功能是为胚胎提供合适的环境，最终导致后代的出生和物种的成功繁殖。要做到这一点，就必须在子宫内膜和子宫肌层这两个器官的组成部分内精确协调激素信号。非编码RNA，特别是microRNA（miRNAs）已被证明对正常子宫发育和功能至关重要。在这个器官中，miRNAs被提议微调雌性类固醇激素雌二醇和孕酮的作用。并不令人惊讶的是，miRNAs的错误表达已经分别在子宫内膜和子宫肌层疾病如子宫内膜异位症和平滑肌瘤中被记录。在这一章中，我将回顾目前的理解的作用，调节和功能的非编码RNA集中在两个正常生理的子宫内膜和子宫肌层，以及在这些组织的病理，即子宫内膜异位症和平滑肌瘤的miRNA。
The major function of the uterus is to accept and provide a suitable environment for an embryo, ultimately leading the birth of offspring and successful propagation of the species. For this occur, there must be precise coordination of hormonal signalling within both the endometrial and myometrial components of this organ. Non-coding RNAs, specifically, microRNAs (miRNAs) have been shown to be essential for normal uterine development and function. Within this organ, miRNAs are proposed to fine-tune the actions of the female steroid hormones estradiol and progesterone. Not surprising, mis-expression of miRNAs has been documented in diseases of the endometrium and myometrium such as endometriosis and leiomyomas, respectively. In this chapter, I will review the current understanding on the role, regulation and function of non-coding RNAs focusing on miRNAs in both the normal physiology of the endometrium and myometrium as well as in pathologies of these tissues, namely endometriosis and leiomyomas.