Schizophrenia-schizoaffective-bipolar spectra: an epistemological perspective
Schizophrenia-schizoaffective-bipolar spectra: an epistemological perspective
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DOI：
10.1017/s1092852919001408
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发表时间：
2021-06-01
期刊：
影响因子：
3.3
通讯作者：
Ouakinin, Silvia
中科院分区：
文献类型：
--
作者：
Gama Marques, Joao;Ouakinin, Silvia
几十年来，临床医生和研究人员一直在思考和撰写有关精神分裂症的疾病谱。事实上，克雷佩林和布莱德利都认为精神分裂症是一个谱系，既有临床（个体）的，也有遗传（家族）的连续体，从一些精致的人格特征到毫无疑问的慢性和衰弱的精神病。其他作者将精神分裂症谱系障碍放在不同的连续体水平上：发展的，心理功能的，存在的和遗传的。在这里，我们想提出一个历史年表的精神分裂症-情感障碍-双极光谱加上三维模型，这些光谱：第一轴的类别（情感与非情感性精神病），第二轴的维度（个性与全面爆发的精神病），和第三轴的生物标志物（缓解与复发）。我们相信，如果没有精神分裂症-情感障碍-双相情感障碍的概念，我们所有的努力都将失败，这是一个最困难的任务：寻找精神分裂症和相关疾病的生物标志物。
For decades clinicians and researchers have been thinking and writing about the spectrum of schizophrenia disorders. Indeed both Kraepelin and Bleuler believed in schizophrenia as a spectrum, both in a clinical (individual) and hereditary (family) continuum, from just some exquisite personality traits to unquestionable chronic and debilitating psychosis. Other authors would put the schizophrenia spectrum disorders on different levels of continuum: developmental, psychofunctional, existential, and genetic. Here, we would like to present an historical chronology for the schizophrenia-schizoaffective-bipolar spectra plus a tridimensional model for these spectra: the first axis for categories (affective versus nonaffective psychoses), the second axis for dimensions (personality versus full blown psychosis), and a third axis for biomarkers (remission versus relapse). We believe that without the schizophrenia-schizoaffective-bipolar spectra concept in our minds all our efforts will keep failing one the hardest quest: searching for biomarkers in schizophrenia and related disorders.