The Immunology of Mammary Gland of Dairy Ruminants between Healthy and Inflammatory Conditions.
The Immunology of Mammary Gland of Dairy Ruminants between Healthy and Inflammatory Conditions.
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DOI：
10.1155/2014/659801
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Barros-Velázquez J
中科院分区：
文献类型：
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作者：
Ezzat Alnakip M;Quintela-Baluja M;Böhme K;Fernández-No I;Caamaño-Antelo S;Calo-Mata P;Barros-Velázquez J
产奶动物的健康，特别是产奶乳腺的健康，对乳品行业至关重要，因为确保生产高质量牛奶的卫生和经济方面至关重要。由于其高患病率，乳腺炎被认为是对乳品工业的最重要的威胁，由于其对动物健康和牛奶生产的影响，从而对经济效益的影响。MG受到几种防御机制的保护，防止微生物渗透和监视。然而，有几个因素可以减弱宿主的免疫反应（IR），并拥有不同的致病性和耐药因子的不同乳腺炎引起的微生物大大限制了免疫防御，并促进乳房内感染（IMIs）的建立。全面了解健康和炎症条件下的MG免疫将是理解特定病原体引起的IMI性质的重要关键，并极大地有助于开发有效的控制方法和适当的检测技术。因此，本综述旨在提供一个详细的概述抗菌防御MG在健康和炎症条件下。在这个意义上说，我们将集中在病原体依赖的变化，由主机安装在IMI和讨论这些变化的潜在后果。
The health of dairy animals, particularly the milk-producing mammary glands, is essential to the dairy industry because of the crucial hygienic and economic aspects of ensuring production of high quality milk. Due to its high prevalence, mastitis is considered the most important threat to dairy industry, due to its impacts on animal health and milk production and thus on economic benefits. The MG is protected by several defence mechanisms that prevent microbial penetration and surveillance. However, several factors can attenuate the host immune response (IR), and the possession of various virulence and resistance factors by different mastitis-causing microorganisms greatly limits immune defences and promotes establishment of intramammary infections (IMIs). A comprehensive understanding of MG immunity in both healthy and inflammatory conditions will be an important key to understand the nature of IMIs caused by specific pathogens and greatly contributes to the development of effective control methods and appropriate detection techniques. Consequently, this review aims to provide a detailed overview of antimicrobial defences in the MG under healthy and inflammatory conditions. In this sense, we will focus on pathogen-dependent variations in IRs mounted by the host during IMI and discuss the potential ramifications of these variations.