Dopamine synthesis, uptake, metabolism, and receptors: Relevance to gene therapy of Parkinson's disease
Dopamine synthesis, uptake, metabolism, and receptors: Relevance to gene therapy of Parkinson's disease
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DOI：
10.1006/exnr.1996.6379
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发表时间：
1997-03-01
影响因子：
5.3
通讯作者：
Roth, RH
中科院分区：
文献类型：
--
作者：
Elsworth, JD;Roth, RH
本文简要概述了目前对多巴胺分子生命周期的理解，包括多巴胺的合成，储存，释放，受体和自身受体的相互作用，以及再摄取。特别考虑的生化变化，发生在黑质纹状体多巴胺系统在帕金森氏症和基因治疗如何可能提供一个新的策略，扭转帕金森氏症的生化缺陷。(C)北京：科学出版社.
This article gives a brief overview of the current understanding of the life cycle of the dopamine molecule, covering dopamine synthesis, storage, release, receptor and autoreceptor interactions, and reuptake. Special consideration is given to biochemical changes that occur in the nigrostriatal dopamine system in Parkinson's disease and how gene therapy may provide a new strategy for reversing parkinsonian biochemical deficits. (C) 1997 Academic Press.